Hypothesis #3962

curcumin → TDP-43 → skeletal muscle atrophy

Drug domain: Alzheimer Outcome domain: ALS Score: 0.208 Quality: mid

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Provenance trace

Audit trail · curcumin → TDP-43 → skeletal muscle atrophy

2 source papers, 2 extracted claims, scored by Swanson ABC chain.

Backfilled

Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.

1Source papers2
Filter
2Extracted claims2

Each row is one structured triple extracted by deepseek-v4-flash (prompt v1_2026_05_07, source: configured). Confidence is the LLM's self-rating.

  • curcuminbinds_toTDP-43A→B
    "in frontotemporal lobar degeneration brains with TDP-43 inclusions"polarity: negativeconfidence 0.90· extraction run #16· claim #40575
  • TDP-43associated_withskeletal muscle atrophyB→C
    "in rNLS8 mouse model"confidence 0.80· extraction run #15· claim #33876
3Bridging logicSwanson ABC
Drug
curcumin
binds_to
→
1 paper
Mediator
TDP-43
associated_with
→
1 paper
Outcome
skeletal muscle atrophy
edge_support_log_ab
log(ab + 1) = 0.693
edge_support_log_bc
log(bc + 1) = 0.693
novelty_factor
1.000 (no direct drug→outcome evidence — full novelty)
direct_a_to_c_count
0
4Embedding modelbge-m3

Embeddings are used at the L1 filtering stage to prune off-topic abstracts before claim extraction. They do not directly score the hypothesis.

model
bge-m3
dim
1024
max_length
8192 tokens
similarity_scores
No per-hypothesis cosine scores stored.
5Final scoringmid · 0.208
method
swanson_abc_log_evidence_with_novelty_penalty
formula
score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)
raw score
0.1386
outreach score
0.2079
quality tier
mid
Pipeline version
9996ffa
Pipeline run
id 4 · uuid eb8b7730…
Pipeline command
scripts/backfill_provenance_v2.py:v2_2026_05_12
Pipeline status
completed
Generated
2026-05-12 21:43:39 UTC
Schema version
1.0
Download full provenance JSON

Horizontal exploration

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Show 3 more
  1. New indication0.83
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  2. New indication0.83
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Score trajectory

How this hypothesis evolved

First captured May 11, 2026, latest May 13, 2026. 3 snapshots.

0.000.100.200.3001122 score evidence count May 11, 2026 · score 0.208 · 2 evidence · CT: preclinical_only · Lit: partial_evidenceMay 11freezeMay 12, 2026 · score 0.208 · 2 evidence · CT: preclinical_only · Lit: partial_evidenceMay 12freezeMay 13, 2026 · score 0.208 · 2 evidence · CT: preclinical_only · Lit: partial_evidenceMay 13monthly
Score (left axis) Evidence count (right axis, dashed)