Featured hypothesis case studies
Deep-dives into selected hypotheses from the Robertium catalog — drug → mediator → outcome chains presented as evidence chains with external references to authoritative sources (Wikipedia, DrugBank, UniProt, MeSH).
Section 1
Top novel candidate hypotheses
Novel candidate high
Auranofin → TDP-43 → ALS
Rheumatoid arthritis → ALS
Novel candidate high
carbamazepine → KRAS → pancreatic ductal adenocarcinoma
Epilepsy → Pancreatic cancer
Novel candidate high
curcumin → TDP-43 → ALS
Alzheimer → ALS
Novel candidate high
Ketogenic diet → Sod1 → ALS
Epilepsy → ALS
Section 2
Benchmark validation hits
Benchmark hit low
ketamine → NMDA receptor → pain
Depression → ALS
Benchmark hit low
Fingolimod → HMGB1 → ALS
Multiple sclerosis → ALS
For the full benchmark validation story — including how the v1 and v2 architectural choices were tested — see /benchmark.