CROSS-DOMAIN PATTERN
Same drug, multiple disease domains
pridopidine appears in hypotheses across 3 disease domains: Alzheimer, Epilepsy, Glioblastoma. Shared mediators that recur across at least two of those domains: sigma-1 receptor.
Aggregated from the catalog. Biological interpretation of any multi-indication mechanism would require independent validation — this is a structural observation only.
ALL HYPOTHESES
Repurposing candidates for pridopidine
Alzheimer 1
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| sigma-1 receptor | Alzheimer's disease | 0.208 | Mid | reproduces known | none |
Epilepsy 1
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| sigma-1 receptor | seizure susceptibility | 0.208 | Mid | novel signal | none |
Glioblastoma 1
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| sigma-1 receptor | glioblastoma | 0.248 | Mid | novel signal | none |