DRUG

CLR01

33 hypotheses across 4 therapeutic domains

CROSS-DOMAIN PATTERN

Same drug, multiple disease domains

CLR01 appears in hypotheses across 4 disease domains: ALS, Depression, Epilepsy, Multiple sclerosis. Shared mediators that recur across at least two of those domains: TAU.

Aggregated from the catalog. Biological interpretation of any multi-indication mechanism would require independent validation — this is a structural observation only.

ALL HYPOTHESES

Repurposing candidates for CLR01

ALS 5

Mediator Outcome Score Tier Lit. status Trial
TAU Alzheimer's disease 0.248 Mid reproduces known none
TAU neurodegenerative diseases 0.208 Mid partial evidence none
TAU protein aggregation 0.208 Mid reproduces known none
tau neurodegenerative diseases 0.208 Mid partial evidence none
TAU Kii ALS/PDC 0.208 Mid novel signal none

Depression 1

Mediator Outcome Score Tier Lit. status Trial
TAU late-life depression 0.208 Mid novel signal none

Epilepsy 24

Mediator Outcome Score Tier Lit. status Trial
TAU memory performance 0.248 Mid novel signal none
TAU seizure generation 0.208 Mid novel signal none
TAU subiculum thickness 0.208 Mid novel signal none
TAU neuronal hyperexcitability 0.208 Mid novel signal none
TAU posterior hippocampal atrophy 0.208 Mid novel signal none
TAU neuronal injury severity 0.208 Mid novel signal none
TAU seizures 0.208 Mid novel signal none
TAU BA35 thickness 0.208 Mid novel signal none
TAU global neurodegeneration 0.208 Mid novel signal none
TAU entorhinal cortex atrophy 0.208 Mid novel signal none
TAU glucose metabolism 0.208 Mid novel signal none
TAU hippocampal volume 0.208 Mid novel signal none
TAU MTL neurodegeneration 0.208 Mid novel signal none
TAU entorhinal cortex volume 0.208 Mid novel signal none
TAU ERC thickness 0.208 Mid novel signal none
TAU Braak staging 0.208 Mid novel signal none
TAU cognitive scores 0.208 Mid novel signal none
TAU excitation/inhibition imbalance 0.208 Mid novel signal none
TAU increased glucose metabolism 0.208 Mid novel signal none
TAU memory 0.208 Mid novel signal none
TAU cognition 0.208 Mid novel signal none
TAU hypometabolism 0.208 Mid novel signal none
TAU SRLM thickness 0.208 Mid novel signal none
TAU object memory impairment 0.208 Mid novel signal none

Multiple sclerosis 3

Mediator Outcome Score Tier Lit. status Trial
TAU secondary-progressive multiple sclerosis 0.208 Mid novel signal none
TAU multiple sclerosis progression 0.208 Mid novel signal none
TAU Multiple Sclerosis 0.208 Mid novel signal none

Clinical trials

0 registered trials for CLR01

Source: ClinicalTrials.gov

No registered trials found on ClinicalTrials.gov. This could indicate either an unexplored indication or a gap in registry coverage.

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