saxagliptin → SOD1 → familial amyotrophic lateral sclerosis

• Genetic Epidemiology of Amyotrophic Lateral Sclerosis in Norway: A 2-Year Population-Based Study

  B→C
  Neuroepidemiology· 2022· PMID 35576897· doi
• SOD1 in amyotrophic lateral sclerosis development – in silico analysis and molecular dynamics of A4F and A4V variants

  B→C
  J Cell Biochem· 2019· PMID 31134679· doi
• The synergistic effects of saxagliptin and metformin on CD34+ endothelial progenitor cells in early type 2 diabetes patients: a randomized clinical trial

  A→B
  Cardiovasc Diabetol· 2018· PMID 29724198· doi
• A novel D90_K91insN mutation in exon 4 of the <i>SOD1</i> gene caused familial amyotrophic lateral sclerosis in a Chinese pedigree

  B→C
  Amyotroph Lateral Scler Frontotemporal Degener· 2018· PMID 29609497· doi
• Molecular dynamics of a far positioned SOD1 mutant V14M reveals pathogenic misfolding behavior

  B→C
  J Biomol Struct Dyn· 2017· PMID 29157189· doi
• Identification of L84F mutation with a novel nucleotide change c.255G &gt; T in the superoxide dismutase gene in a North Indian family with amyotrophic lateral sclerosis

  B→C
  Amyotroph Lateral Scler Frontotemporal Degener· 2015· PMID 26630559· doi

Each row is one structured triple extracted by deepseek-v4-flash (prompt v1_2026_05_07, source: configured). Confidence is the LLM's self-rating.

• saxagliptinupregulatesSOD1A→B
  "in CD34+ cells from early type 2 diabetes patients treated with metformin"confidence 0.90· extraction run #27· claim #193190
• SOD1associated_withfamilial amyotrophic lateral sclerosisB→C
  "in Norwegian ALS patients"confidence 0.75· extraction run #15· claim #32940
• SOD1causesfamilial amyotrophic lateral sclerosisB→C
  "in humans"confidence 0.90· extraction run #15· claim #33305
• SOD1associated_withfamilial amyotrophic lateral sclerosisB→C
  "North Indian family"confidence 0.95· extraction run #21· claim #97967
• SOD1associated_withfamilial amyotrophic lateral sclerosisB→C
  "in silico analysis of A4F and A4V variants"confidence 0.90· extraction run #21· claim #98773
• SOD1causesfamilial amyotrophic lateral sclerosisB→C
  "Chinese pedigree with autosomal dominant inheritance and reduced penetrance"confidence 0.95· extraction run #21· claim #101174

No claims match this filter.

edge_support_log_ab

log(ab + 1) = 0.693

edge_support_log_bc

log(bc + 1) = 1.792

novelty_factor

1.000 (no direct drug→outcome evidence — full novelty)

direct_a_to_c_count

0

Embeddings are used at the L1 filtering stage to prune off-topic abstracts before claim extraction. They do not directly score the hypothesis.

model

bge-m3

dim

1024

max_length

8192 tokens

similarity_scores

No per-hypothesis cosine scores stored.

method

swanson_abc_log_evidence_with_novelty_penalty

formula

score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)

raw score

0.2485

outreach score

0.2485

quality tier

mid