VPA → TREM2 → Alzheimer's disease

• TREM2 gene expression associations with Alzheimer’s disease neuropathology are region-specific: implications for cortical versus subcortical microglia

  B→C
  Acta Neuropathol· 2023· PMID 36966244· doi
• Prenatally VPA exposure is likely to cause autistic-like behavior in the rats offspring via TREM2 down-regulation to affect the microglial activation and synapse alterations

  A→B
  Environ Toxicol Pharmacol· 2023· PMID 36870407· doi
• Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading

  B→C
  J Exp Med· 2022· PMID 36219197· doi
• Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease

  B→C
  Nat Genet· 2022· PMID 36411364· doi
• Microglia and its Genetics in Alzheimer's Disease

  B→C
  Curr Alzheimer Res· 2021· PMID 34749609· doi
• Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer’s disease

  B→C
  Cell Rep· 2021· PMID 33567283· doi

Each row is one structured triple extracted by deepseek-v4-flash (prompt v1_2026_05_07, source: configured). Confidence is the LLM's self-rating.

• VPAdownregulatesTREM2A→B
  "prenatal exposure in rat offspring"confidence 0.95· extraction run #14· claim #16412
• TREM2associated_withAlzheimer's diseaseB→C
  "exome sequencing of 32,558 individuals (16,036 AD cases and 16,522 controls)"confidence 0.90· extraction run #16· claim #37456
• TREM2associated_withAlzheimer's diseaseB→C
  "late-onset"confidence 0.90· extraction run #16· claim #38247
• Trem2associated_withAlzheimer's diseaseB→C
  "human AD studies"confidence 0.90· extraction run #16· claim #40521
• TREM2correlates_withAlzheimer's diseaseB→C
  "in dorsolateral prefrontal cortex and posterior cingulate cortex"confidence 0.90· extraction run #16· claim #43352
• TREM2associated_withAlzheimer's diseaseB→C
  "microglia"confidence 0.90· extraction run #16· claim #44281

No claims match this filter.

edge_support_log_ab

log(ab + 1) = 0.693

edge_support_log_bc

log(bc + 1) = 1.792

novelty_factor

1.000 (no direct drug→outcome evidence — full novelty)

direct_a_to_c_count

0

Embeddings are used at the L1 filtering stage to prune off-topic abstracts before claim extraction. They do not directly score the hypothesis.

model

bge-m3

dim

1024

max_length

8192 tokens

similarity_scores

No per-hypothesis cosine scores stored.

method

swanson_abc_log_evidence_with_novelty_penalty

formula

score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)

raw score

0.2485

outreach score

0.2485

quality tier

mid