Bevacizumab → VEGF → Alzheimer's disease

• L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy and bevacizumab in newly-diagnosed glioblastoma: expansion of the phase I/II GLORIA trial

  A→B
  Nat Commun· 2026· PMID 41951573· doi
• Incidence of Bevacizumab‐Associated Toxicity in Children With Low‐Grade Glioma With and Without Neurofibromatosis Type 1

  A→B
  Pediatr Blood Cancer· 2025· PMID 41431343· doi
• Blood levels of cytokines highlight the role of inflammation in Alzheimer's disease

  B→C
  Heliyon· 2025· PMID 39872450· doi
• Developing Immunoniosomes (INs): Antibody and Fab conjugations of niosomal nanoparticles via UV-NBS and EDC/NHS chemistry for treating glioblastoma cells

  A→B
  Int J Pharm X· 2025· PMID 40757003· doi
• Metabolic changes and anti-tumor effects of a ketogenic diet combined with anti-angiogenic therapy in a glioblastoma mouse model

  A→B
  Sci Rep· 2021· PMID 33420169· doi
• Glioblastoma: Targeting Angiogenesis and Tyrosine Kinase Pathways

  A→B
  Nov Approaches Cancer Study· 2020· PMID 32924014· doi
• Vascular Endothelial Growth Factor remains unchanged in cerebrospinal fluid of patients with Alzheimer’s disease and vascular dementia

  B→C
  Alzheimers Res Ther· 2018· PMID 29933741· doi

Each row is one structured triple extracted by deepseek-v4-flash (prompt v1_2026_05_07, source: configured). Confidence is the LLM's self-rating.

• bevacizumabinhibitsVEGFA→B
  "glioblastoma mouse model"confidence 0.90· extraction run #7· claim #1415
• bevacizumabinhibitsVEGFA→B
  "in glioblastoma"confidence 0.80· extraction run #9· claim #7551
• Bevacizumabbinds_toVEGFA→B
  "in immunoniosomes for glioblastoma treatment"confidence 0.90· extraction run #9· claim #9630
• Bevacizumabbinds_toVEGFA→B
  "general mechanism"confidence 0.90· extraction run #19· claim #85832
• bevacizumabinhibitsVEGFA→B
  "in newly-diagnosed glioblastoma patients after radiotherapy"confidence 0.95· extraction run #19· claim #87419
• VEGFassociated_withAlzheimer's diseaseB→C
  "plasma levels comparing MCI individuals and Alzheimer's disease patients"confidence 0.90· extraction run #16· claim #46475
• VEGFassociated_withAlzheimer's diseaseB→C
  "cerebrospinal fluid"polarity: negativeconfidence 0.90· extraction run #16· claim #58335

No claims match this filter.

edge_support_log_ab

log(ab + 1) = 1.792

edge_support_log_bc

log(bc + 1) = 1.099

novelty_factor

1.000 (no direct drug→outcome evidence — full novelty)

direct_a_to_c_count

0

Embeddings are used at the L1 filtering stage to prune off-topic abstracts before claim extraction. They do not directly score the hypothesis.

model

bge-m3

dim

1024

max_length

8192 tokens

similarity_scores

No per-hypothesis cosine scores stored.

method

swanson_abc_log_evidence_with_novelty_penalty

formula

score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)

raw score

0.2890

outreach score

0.2890

quality tier

high