CROSS-DOMAIN PATTERN
Same drug, multiple disease domains
lithium appears in hypotheses across 3 disease domains: Alzheimer, Epilepsy, Pancreatic cancer. Shared mediators that recur across at least two of those domains: GSK-3β.
Aggregated from the catalog. Biological interpretation of any multi-indication mechanism would require independent validation — this is a structural observation only.
ALL HYPOTHESES
Repurposing candidates for lithium
Alzheimer 3
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| GSK-3β | Alzheimer's disease | 0.269 | Mid | reproduces known | completed | |
| GSK-3β | tau hyperphosphorylation | 0.269 | Mid | reproduces known | none | |
| GSK-3β | tau spreading | 0.208 | Mid | novel signal | none |
Epilepsy 2
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| GSK-3β | hippocampal damage | 0.208 | Mid | reproduces known | none | |
| GSK-3β | neurodegeneration | 0.208 | Mid | reproduces known | completed |
Pancreatic cancer 2
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| GSK-3β | PanIN progression | 0.208 | Mid | novel signal | none | |
| GSK-3β | acinar-to-ductal metaplasia | 0.208 | Mid | novel signal | none |