DRUG

auraptene

27 hypotheses across 8 therapeutic domains

CROSS-DOMAIN PATTERN

Same drug, multiple disease domains

auraptene appears in hypotheses across 8 disease domains: Alzheimer, Depression, Epilepsy, Inflammatory bowel disease, Multiple sclerosis, Pancreatic cancer, Rheumatoid arthritis, Type 2 diabetes. Shared mediators that recur across at least two of those domains: MMP-9, MMP-2.

Aggregated from the catalog. Biological interpretation of any multi-indication mechanism would require independent validation — this is a structural observation only.

ALL HYPOTHESES

Repurposing candidates for auraptene

Alzheimer 3

Mediator	Outcome	Score	Tier	Lit. status	Trial
MMP-9	Alzheimer's disease	0.269	Mid	partial evidence	none
MMP-9	DSAD	0.208	Mid	novel signal	none
MMP-2	brain amyloid deposition	0.208	Mid	novel signal	none

Depression 6

Mediator	Outcome	Score	Tier	Lit. status	Trial
JNK	social cognition performance	0.208	Mid	novel signal	none
MMP-9	major depressive disorder without recent suicide attempt	0.208	Mid	novel signal	none
MMP-9	inhibitory input to excitatory neurons	0.208	Mid	novel signal	none
MMP-9	perineuronal net	0.208	Mid	novel signal	none
MMP-9	recent suicide attempt	0.208	Mid	novel signal	none
MMP-9	branching of excitatory neurons	0.208	Mid	novel signal	none

Epilepsy 8

Mediator	Outcome	Score	Tier	Lit. status	Trial
MMP-9	epilepsy	0.416	High	partial evidence	none
MMP-9	seizures	0.269	Mid	partial evidence	none
MMP-9	poor prognosis	0.208	Mid	novel signal	none
MMP-9	cognitive function	0.208	Mid	partial evidence	none
MMP-9	synaptic connectivity	0.208	Mid	novel signal	none
MMP-2	epilepsy	0.208	Mid	partial evidence	none
mTOR	neuronal spiking activity	0.208	Mid	novel signal	none
mTOR	mTOR-opathies	0.208	Mid	novel signal	none

Inflammatory bowel disease 2

Mediator	Outcome	Score	Tier	Lit. status	Trial
MMP-9	ulcerative colitis	0.312	High	partial evidence	none
MMP-9	colonic epithelial permeability	0.208	Mid	novel signal	none

Multiple sclerosis 3

Mediator	Outcome	Score	Tier	Lit. status	Trial
MMP-9	Multiple Sclerosis	0.208	Mid	partial evidence	none
MMP-2	multiple sclerosis	0.208	Mid	partial evidence	none
MMP-9	HHV-6 seropositivity	0.208	Mid	novel signal	none

Pancreatic cancer 1

Mediator	Outcome	Score	Tier	Lit. status	Trial
MMP-9	vascular invasion	0.208	Mid	novel signal	none

Rheumatoid arthritis 2

Mediator	Outcome	Score	Tier	Lit. status	Trial
MMP-9	rheumatoid arthritis	0.269	Mid	partial evidence	none
MMP-9	RA	0.208	Mid	partial evidence	none

Type 2 diabetes 2

Mediator	Outcome	Score	Tier	Lit. status	Trial
MMP-2	brachial 24-h pulse pressure	0.208	Mid	novel signal	none
MMP-2	retinopathy	0.208	Mid	partial evidence	none

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