Hypothesis #38829

Auranofin → Nrf2 → disease progression

Drug domain: Rheumatoid arthritis Outcome domain: Multiple sclerosis Score: 0.345 Quality: high

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Provenance trace

Audit trail · Auranofin → Nrf2 → disease progression

5 source papers, 5 extracted claims, scored by Swanson ABC chain.

Backfilled

Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.

1Source papers5
Filter
2Extracted claims5

Each row is one structured triple extracted by deepseek-v4-flash (prompt v1_2026_05_07, source: configured). Confidence is the LLM's self-rating.

  • AuranofinactivatesNrf2A→B
    "in human cytotoxic lymphocytes"confidence 0.95· extraction run #29· claim #208141
  • auranofinactivatesNrf2A→B
    "in mouse B16 melanoma and LLC lung adenocarcinoma cells"confidence 0.80· extraction run #29· claim #208521
  • auranofininducesNRF2A→B
    "in murine alveolar macrophages (MH-S)"confidence 0.90· extraction run #29· claim #220933
  • auranofinactivatesNrf2A→B
    "in peripheral immune cells and CNS in a mouse model of relapsing-remitting EAE"confidence 0.90· extraction run #29· claim #229940
  • NRF2correlates_withdisease progressionB→C
    "in PBMCs from multiple disease contexts"confidence 0.80· extraction run #25· claim #153292
3Bridging logicSwanson ABC
Drug
Auranofin
activates
→
4 papers
Mediator
Nrf2
correlates_with
→
1 paper
Outcome
disease progression
edge_support_log_ab
log(ab + 1) = 1.609
edge_support_log_bc
log(bc + 1) = 0.693
novelty_factor
1.000 (no direct drug→outcome evidence — full novelty)
direct_a_to_c_count
0
4Embedding modelbge-m3

Embeddings are used at the L1 filtering stage to prune off-topic abstracts before claim extraction. They do not directly score the hypothesis.

model
bge-m3
dim
1024
max_length
8192 tokens
similarity_scores
No per-hypothesis cosine scores stored.
5Final scoringhigh · 0.345
method
swanson_abc_log_evidence_with_novelty_penalty
formula
score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)
raw score
0.2303
outreach score
0.3454
quality tier
high
Pipeline version
9996ffa
Pipeline run
id 4 · uuid eb8b7730…
Pipeline command
scripts/backfill_provenance_v2.py:v2_2026_05_12
Pipeline status
completed
Generated
2026-05-12 21:43:40 UTC
Schema version
1.0
Download full provenance JSON

Horizontal exploration

Similar hypotheses

Closest 8 of 1,618 hypotheses, ranked by hybrid score (50% bge-m3 embedding cosine · 40% drug/mediator/outcome overlap · 10% shared evidence papers).

  1. New indication0.90
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    Same drug + same mediator, different disease

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  2. New indication0.90
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  3. New indication0.90
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  4. New indication0.90
    Auranofin→Nrf2→poor prognosis

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    Pancreatic cancerhigh
  5. New indication0.89
    Auranofin→Nrf2→ALS

    Same drug + same mediator, different disease

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Show 3 more
  1. New indication0.88
    Auranofin→Nrf2→chemoresistance

    Same drug + same mediator, different disease

    Pancreatic cancerhigh
  2. Cross-indication0.80
    Auranofin→TXNRD1→resistance

    Same drug, different disease — potential alternate indication

    Pancreatic cancermid
  3. Cross-indication0.80
    Auranofin→Caspase-3→neuronal apoptosis

    Same drug, different disease — potential alternate indication

    ALSmid
Score trajectory

How this hypothesis evolved

First captured May 12, 2026, latest May 13, 2026. 2 snapshots.

0.000.100.200.300.40012345 score evidence count May 12, 2026 · score 0.345 · 5 evidence · CT: none · Lit: reproduces_knownMay 12freezeMay 13, 2026 · score 0.345 · 5 evidence · CT: none · Lit: reproduces_knownMay 13monthly
Score (left axis) Evidence count (right axis, dashed)