CROSS-DOMAIN PATTERN
Same drug, multiple disease domains
pioglitazone appears in hypotheses across 5 disease domains: ALS, Alzheimer, Inflammatory bowel disease, Pancreatic cancer, Rheumatoid arthritis. Shared mediators that recur across at least two of those domains: SIRT1.
Aggregated from the catalog. Biological interpretation of any multi-indication mechanism would require independent validation — this is a structural observation only.
ALL HYPOTHESES
Repurposing candidates for pioglitazone
ALS 1
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| RAGE | ALS | 0.208 | Mid | reproduces known | completed |
Alzheimer 3
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| SIRT1 | Alzheimer's disease | 0.248 | Mid | reproduces known | completed | |
| Rac1 | Alzheimer's disease | 0.208 | Mid | reproduces known | completed | |
| GFAP | Alzheimer's disease | 0.208 | Mid | reproduces known | completed |
Inflammatory bowel disease 1
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| PPAR-γ | disease activity of ulcerative colitis | 0.264 | Mid | novel signal | none |
Pancreatic cancer 1
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| SIRT1 | proliferation | 0.220 | Mid | reproduces known | completed |
Rheumatoid arthritis 1
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| STAT3 | prurigo nodularis | 0.208 | Mid | novel signal | none |