CROSS-DOMAIN PATTERN
Same drug, multiple disease domains
pentamidine appears in hypotheses across 3 disease domains: ALS, Alzheimer, Epilepsy. Shared mediators that recur across at least two of those domains: S100B.
Aggregated from the catalog. Biological interpretation of any multi-indication mechanism would require independent validation — this is a structural observation only.
ALL HYPOTHESES
Repurposing candidates for pentamidine
ALS 2
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| S100B | ALS | 0.277 | High | novel signal | none | |
| S100B | clinical improvement | 0.208 | Mid | reproduces known | none |
Alzheimer 2
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| S100B | lower cognitive performance | 0.208 | Mid | novel signal | none | |
| S100B | tau seeding | 0.208 | Mid | novel signal | none |
Epilepsy 2
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| S100B | epilepsy | 0.248 | Mid | partial evidence | none | |
| S100B | neuroscore recovery | 0.208 | Mid | novel signal | none |