CROSS-DOMAIN PATTERN
Same drug, multiple disease domains
E6011 appears in hypotheses across 3 disease domains: ALS, Inflammatory bowel disease, Pancreatic cancer. Shared mediators that recur across at least two of those domains: fractalkine.
Aggregated from the catalog. Biological interpretation of any multi-indication mechanism would require independent validation — this is a structural observation only.
ALL HYPOTHESES
Repurposing candidates for E6011
ALS 2
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| fractalkine | ALSFRS score | 0.230 | Mid | novel signal | none | |
| fractalkine | ALS | 0.230 | Mid | novel signal | none |
Inflammatory bowel disease 1
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| fractalkine | periodontitis | 0.230 | Mid | novel signal | none |
Pancreatic cancer 2
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| fractalkine | apoptosis | 0.230 | Mid | novel signal | none | |
| fractalkine | proliferation | 0.230 | Mid | novel signal | none |