DMF — drug repurposing hypotheses

CROSS-DOMAIN PATTERN

Same drug, multiple disease domains

DMF appears in hypotheses across 6 disease domains: ALS, Alzheimer, Glioblastoma, Pancreatic cancer, Rheumatoid arthritis, Type 2 diabetes. Shared mediators that recur across at least two of those domains: NRF2, Nrf2.

Aggregated from the catalog. Biological interpretation of any multi-indication mechanism would require independent validation — this is a structural observation only.

ALL HYPOTHESES

Repurposing candidates for DMF

ALS 3

Mediator	Outcome	Score	Tier	Lit. status	Trial
NRF2	ALS	0.230	Mid	partial evidence	none
NRF2	antioxidant defense	0.230	Mid	reproduces known	none
NRF2	neurodegenerative processes	0.208	Mid	novel signal	none

Alzheimer 1

Mediator	Outcome	Score	Tier	Lit. status	Trial
NRF2	Alzheimer's disease	0.230	Mid	reproduces known	active

Glioblastoma 1

Mediator	Outcome	Score	Tier	Lit. status	Trial
NRF2	patient survival	0.208	Mid	partial evidence	none

Pancreatic cancer 7

Mediator	Outcome	Score	Tier	Lit. status	Trial
NRF2	chemoresistance	0.271	High	partial evidence	none
Nrf2	chemoresistance	0.271	High	partial evidence	none
NRF2	poor prognosis	0.230	Mid	reproduces known	none
Nrf2	poor prognosis	0.230	Mid	reproduces known	none
NRF2	5-FU resistance	0.208	Mid	novel signal	none
NRF2	cell proliferation	0.208	Mid	reproduces known	none
NRF2	poor survival	0.208	Mid	partial evidence	none

Rheumatoid arthritis 7

Mediator	Outcome	Score	Tier	Lit. status	Trial
Nrf2	rheumatoid arthritis	0.271	High	reproduces known	completed
Nrf2	disease activity	0.271	High	reproduces known	active
Nrf2	toxicity of conventional anti-rheumatic therapies	0.230	Mid	novel signal	none
Nrf2	drug efflux	0.230	Mid	novel signal	none
Nrf2	efficacy of synthetic anti-rheumatic drugs	0.230	Mid	novel signal	none
Nrf2	interstitial lung disease	0.230	Mid	novel signal	none
STAT3	prurigo nodularis	0.208	Mid	novel signal	none

Type 2 diabetes 3

Mediator	Outcome	Score	Tier	Lit. status	Trial
Nrf2	type 1 diabetes	0.230	Mid	reproduces known	active
Nrf2	lipid accumulation	0.208	Mid	partial evidence	none
Nrf2	diabetic cardiomyopathy	0.208	Mid	partial evidence	none

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