cisplatin — drug repurposing hypotheses

CROSS-DOMAIN PATTERN

Same drug, multiple disease domains

cisplatin appears in hypotheses across 5 disease domains: ALS, Alzheimer, Epilepsy, Inflammatory bowel disease, Pancreatic cancer. Shared mediators that recur across at least two of those domains: caspase-3, PD-L1.

Aggregated from the catalog. Biological interpretation of any multi-indication mechanism would require independent validation — this is a structural observation only.

ALL HYPOTHESES

Repurposing candidates for cisplatin

ALS 2

Mediator	Outcome	Score	Tier	Lit. status	Trial
caspase-3	neuronal apoptosis	0.208	Mid	reproduces known	none
caspase-3	Alzheimer's disease	0.208	Mid	reproduces known	none

Alzheimer 1

Mediator	Outcome	Score	Tier	Lit. status	Trial
caspase-3	dendritic spine loss	0.208	Mid	partial evidence	none

Epilepsy 1

Mediator	Outcome	Score	Tier	Lit. status	Trial
caspase-3	drug-resistant epilepsy	0.208	Mid	partial evidence	none

Inflammatory bowel disease 1

Mediator	Outcome	Score	Tier	Lit. status	Trial
PD-L1	colitis	0.269	Mid	reproduces known	none

Pancreatic cancer 3

Mediator	Outcome	Score	Tier	Lit. status	Trial
PD-L1	poor differentiation	0.269	Mid	reproduces known	none
PD-L1	type 2 autoimmune pancreatitis	0.269	Mid	novel signal	none
PD-L1	cancer-specific survival	0.208	Mid	reproduces known	completed

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