Chlorotoxin — drug repurposing hypotheses

CROSS-DOMAIN PATTERN

Same drug, multiple disease domains

Chlorotoxin appears in hypotheses across 7 disease domains: Alzheimer, Epilepsy, Inflammatory bowel disease, Multiple sclerosis, Pancreatic cancer, Rheumatoid arthritis, Type 2 diabetes. Shared mediators that recur across at least two of those domains: MMP-2.

Aggregated from the catalog. Biological interpretation of any multi-indication mechanism would require independent validation — this is a structural observation only.

ALL HYPOTHESES

Repurposing candidates for Chlorotoxin

Alzheimer 2

Mediator	Outcome	Score	Tier	Lit. status	Trial
MMP-2	Alzheimer's disease	0.208	Mid	partial evidence	none
MMP-2	brain amyloid deposition	0.208	Mid	novel signal	none

Epilepsy 1

Mediator	Outcome	Score	Tier	Lit. status	Trial
MMP-2	epilepsy	0.208	Mid	novel signal	none

Inflammatory bowel disease 1

Mediator	Outcome	Score	Tier	Lit. status	Trial
MMP-2	Crohn's disease	0.208	Mid	novel signal	none

Multiple sclerosis 1

Mediator	Outcome	Score	Tier	Lit. status	Trial
MMP-2	Multiple Sclerosis	0.208	Mid	novel signal	none

Pancreatic cancer 7

Mediator	Outcome	Score	Tier	Lit. status	Trial
MMP-2	female gender	0.208	Mid	novel signal	none
MMP-2	histopathological type of cancer	0.208	Mid	novel signal	none
MMP-2	perineural invasion	0.208	Mid	novel signal	none
MMP-2	pancreatic cancer	0.208	Mid	novel signal	completed
MMP-2	lymph node metastasis	0.208	Mid	novel signal	none
MMP-2	inflammation	0.208	Mid	partial evidence	none
MMP-2	survival	0.208	Mid	reproduces known	none

Rheumatoid arthritis 1

Mediator	Outcome	Score	Tier	Lit. status	Trial
MMP-2	rheumatoid arthritis	0.208	Mid	partial evidence	none

Type 2 diabetes 8

Mediator	Outcome	Score	Tier	Lit. status	Trial
MMP-2	office pulse pressure	0.208	Mid	novel signal	none
MMP-2	albuminuria	0.208	Mid	novel signal	none
MMP-2	cardiovascular events	0.208	Mid	novel signal	none
MMP-2	all-cause mortality	0.208	Mid	novel signal	none
MMP-2	pre-hypertension	0.208	Mid	novel signal	none
MMP-2	brachial 24-h pulse pressure	0.208	Mid	novel signal	none
MMP-2	central 24-h pulse pressure	0.208	Mid	novel signal	none
MMP-2	retinopathy	0.208	Mid	novel signal	none

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