Fingolimod → HMGB1 → ALS
Cross-domain hypothesis: Multiple sclerosis drug → ALS outcome
Evidence network
The full set of scientific papers supporting this hypothesis, visualized as a force-directed graph. Each gray node is one paper; hover for the extracted claim, click to open it on PubMed.
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A→B papers (1)
- PMID 39207074 — Fingolimod Alleviates Inflammation after Cerebral Ischemia via HMGB1/TLR4/NF-κB Signaling Pathway (2024) · in hippocampus of MCAO/R rats conf 0.90
B→C papers (2)
- PMID 35216298 — The Involvement of RAGE and Its Ligands during Progression of ALS in SOD1 G93A Transgenic Mice (2022) · at onset in SOD1 G93A mouse lumbar spinal cord conf 0.90
- PMID 26733811 — Receptor for Advanced Glycation End Products and its Inflammatory Ligands are Upregulated in Amyotrophic Lateral Sclerosis (2015) · in spinal cords of ALS patients conf 0.90
No registered trials found on ClinicalTrials.gov. This could indicate either an unexplored indication or a gap in registry coverage.
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Provenance trace not available for hypothesis 23443.
Evidence
Limited evidence base in our current extraction. Treat this hypothesis as a starting point for further literature review, not a settled conclusion.
A → B evidence: Fingolimod downregulates HMGB1
- PMID 39207074 Fingolimod Alleviates Inflammation after Cerebral Ischemia via HMGB1/TLR4/NF-κB Signaling Pathway (2024)
B → C evidence: HMGB1 correlates with ALS
- PMID 35216298 The Involvement of RAGE and Its Ligands during Progression of ALS in SOD1 G93A Transgenic Mice (2022)
- PMID 26733811 Receptor for Advanced Glycation End Products and its Inflammatory Ligands are Upregulated in Amyotrophic Lateral Sclerosis (2015)
References
All PMID-linked papers cited in the evidence network above, deduplicated and sorted by publication year.
- PMID 39207074 Fingolimod Alleviates Inflammation after Cerebral Ischemia via HMGB1/TLR4/NF-κB Signaling Pathway (2024) A→B
- PMID 35216298 The Involvement of RAGE and Its Ligands during Progression of ALS in SOD1 G93A Transgenic Mice (2022) B→C
- PMID 26733811 Receptor for Advanced Glycation End Products and its Inflammatory Ligands are Upregulated in Amyotrophic Lateral Sclerosis (2015) B→C
Limitations & disclaimer
This hypothesis was generated algorithmically through cross-domain literature analysis and has not been experimentally validated. Treat it as a starting point for further investigation, not a therapeutic recommendation. For established knowledge about each entity, refer to the authoritative sources linked above (Wikipedia, DrugBank, UniProt, MeSH).