ALL HYPOTHESES
Repurposing candidates for zonisamide
ALS 4
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| Cx43 | ALS | 0.277 | High | novel signal | none | |
| Cx43 | glutamate-mediated motor neuron toxicity | 0.208 | Mid | novel signal | none | |
| Cx43 | gap junction coupling | 0.208 | Mid | novel signal | none | |
| Cx43 | hemichannel-mediated activity | 0.208 | Mid | novel signal | none |
Glioblastoma 3
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| Cx43 | chemotherapy resistance | 0.208 | Mid | novel signal | none | |
| Cx43 | therapy resistance | 0.208 | Mid | partial evidence | preclinical only | |
| Cx43 | glioma progression | 0.208 | Mid | novel signal | none |