chloroquine — drug repurposing hypotheses

CROSS-DOMAIN PATTERN

Same drug, multiple disease domains

chloroquine appears in hypotheses across 8 disease domains: ALS, Alzheimer, Depression, Epilepsy, Glioblastoma, Inflammatory bowel disease, Rheumatoid arthritis, Type 2 diabetes. Shared mediators that recur across at least two of those domains: IL-10.

Aggregated from the catalog. Biological interpretation of any multi-indication mechanism would require independent validation — this is a structural observation only.

ALL HYPOTHESES

Repurposing candidates for chloroquine

ALS 3

Mediator	Outcome	Score	Tier	Lit. status	Trial
IL-10	microglial burden	0.208	Mid	novel signal	none
IL-10	survival	0.208	Mid	reproduces known	completed
IL-10	lifespan	0.208	Mid	reproduces known	none

Alzheimer 1

Mediator	Outcome	Score	Tier	Lit. status	Trial
IL-10	cognitive decline	0.208	Mid	partial evidence	none

Depression 5

Mediator	Outcome	Score	Tier	Lit. status	Trial
IL-10	hippocampal dendritic spine density	0.208	Mid	novel signal	none
IL-10	bipolar disorder	0.208	Mid	partial evidence	none
IL-10	suicidality	0.208	Mid	novel signal	none
IL-10	depression severity	0.208	Mid	novel signal	none
IL-10	therapeutic efficacy	0.208	Mid	reproduces known	active

Epilepsy 1

Mediator	Outcome	Score	Tier	Lit. status	Trial
IL-10	epileptogenesis	0.208	Mid	partial evidence	none

Glioblastoma 2

Mediator	Outcome	Score	Tier	Lit. status	Trial
IL-10	glioblastoma	0.208	Mid	reproduces known	completed
IL-10	tumor immune escape	0.208	Mid	partial evidence	none

Inflammatory bowel disease 1

Mediator	Outcome	Score	Tier	Lit. status	Trial
IL-10	colitis	0.269	Mid	reproduces known	active

Rheumatoid arthritis 2

Mediator	Outcome	Score	Tier	Lit. status	Trial
IL-10	rheumatoid arthritis	0.269	Mid	reproduces known	active
IL-10	depressive symptoms	0.269	Mid	novel signal	none

Type 2 diabetes 2

Mediator	Outcome	Score	Tier	Lit. status	Trial
IL-10	pain behavior	0.208	Mid	partial evidence	none
IL-10	Type 2 Diabetes Mellitus	0.208	Mid	reproduces known	active

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