CROSS-DOMAIN PATTERN
Same drug, multiple disease domains
5-ASA appears in hypotheses across 3 disease domains: Epilepsy, Multiple sclerosis, Rheumatoid arthritis. Shared mediators that recur across at least two of those domains: miR-155.
Aggregated from the catalog. Biological interpretation of any multi-indication mechanism would require independent validation — this is a structural observation only.
ALL HYPOTHESES
Repurposing candidates for 5-ASA
Epilepsy 1
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| miR-155 | epilepsy | 0.220 | Mid | novel signal | preclinical only |
Multiple sclerosis 1
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| miR-155 | multiple sclerosis | 0.220 | Mid | partial evidence | completed |
Rheumatoid arthritis 1
| Mediator | Outcome | Score | Tier | Lit. status | Trial | |
|---|---|---|---|---|---|---|
| miR-155 | rheumatoid arthritis | 0.220 | Mid | reproduces known | completed |