{"schema_version":"1.0","hypothesis_id":8807,"triple":{"drug":"F-Florzolotau","drug_canonical":"f-florzolotau","mediator":"TAU","mediator_canonical":"MAPT","outcome":"Alzheimer's disease","outcome_canonical":"Alzheimer disease"},"domain":{"domain":"cross_domain","source":"alzheimer","target":"als"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1111/jnc.70350","pmid":"41532955","year":2026,"roles":["mediator_outcome"],"title":"Unveiling the Proteomic Landscape of Extracellular Vesicles: Implications for Neurodegeneration and Neuroprotection","journal":"J Neurochem","work_id":143716,"publication_date":"2026-01-01"},{"doi":"10.1093/braincomms/fcaf015","pmid":"39850631","year":2024,"roles":["drug_mediator"],"title":"Clinical characteristics and biomarker profile in early- and late-onset Alzheimer’s disease: the Shanghai Memory Study","journal":"Brain Commun","work_id":158971,"publication_date":"2024-12-24"},{"doi":"10.1002/mds.30055","pmid":"39555939","year":2024,"roles":["drug_mediator"],"title":"<scp><sup>18</sup>F</scp>‐Florzolotau <scp>PET</scp> Imaging Unveils Tau Pathology in Dementia with Lewy Bodies","journal":"Mov Disord","work_id":158701,"publication_date":"2024-11-18"},{"doi":null,"pmid":"26705184","year":2015,"roles":["mediator_outcome"],"title":"[Histopathological and immunohistochemical study of spinal cord tissues in neurodegenerative diseases].","journal":"Zhonghua Bing Li Xue Za Zhi","work_id":139568,"publication_date":"2015-08-01"}],"source_paper_count":4,"extracted_claims":[{"side":"drug_mediator","object":"tau","context":"in DLB brain","subject":"F-Florzolotau","work_id":158701,"claim_id":110550,"polarity":"positive","predicate":"binds_to","confidence":0.85,"extraction_run_id":22},{"side":"drug_mediator","object":"tau","context":"in precuneus, posterior cingulate cortex, angular gyrus of early-onset Alzheimer's disease","subject":"F-florzolotau","work_id":158971,"claim_id":110975,"polarity":"positive","predicate":"binds_to","confidence":0.6,"extraction_run_id":22},{"side":"mediator_outcome","object":"Alzheimer's disease","context":"in spinal cord neurofibrillary tangles","subject":"tau","work_id":139568,"claim_id":101605,"polarity":"positive","predicate":"associated_with","confidence":0.8,"extraction_run_id":21},{"side":"mediator_outcome","object":"Alzheimer's disease","context":"in Alzheimer's disease","subject":"tau","work_id":143716,"claim_id":102863,"polarity":"positive","predicate":"associated_with","confidence":0.8,"extraction_run_id":21}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[21,22]},"bridge":{"a_to_b_predicate":"binds_to","b_to_c_predicate":"associated_with","a_to_b_evidence_count":2,"b_to_c_evidence_count":2,"edge_support_log_ab":1.0986122886681098,"edge_support_log_bc":1.0986122886681098,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.21972245773362195,"score":0.21972245773362195,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:40.211207+00:00"}