{"schema_version":"1.0","hypothesis_id":8055,"triple":{"drug":"Riluzole","drug_canonical":"riluzole","mediator":"CK1δ","mediator_canonical":"ck1δ","outcome":"pancreatic cancer","outcome_canonical":"pancreatic cancer"},"domain":{"domain":"cross_domain","source":"als","target":"pancreatic_cancer"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1158/1535-7163.mct-19-0997","pmid":"32430484","year":2020,"roles":["mediator_outcome"],"title":"Targeting Casein Kinase 1 Delta Sensitizes Pancreatic and Bladder Cancer Cells to Gemcitabine Treatment by Upregulating Deoxycytidine Kinase","journal":"Mol Cancer Ther","work_id":177411,"publication_date":"2020-05-19"},{"doi":"10.4103/1673-5374.262578","pmid":"31397342","year":2019,"roles":["drug_mediator"],"title":"Rethinking to riluzole mechanism of action: the molecular link among protein kinase CK1δ activity, TDP-43 phosphorylation, and amyotrophic lateral sclerosis pharmacological treatment","journal":"Neural Regen Res","work_id":52074,"publication_date":"2019-01-01"},{"doi":"10.1002/cmdc.201800632","pmid":"30359484","year":2018,"roles":["drug_mediator"],"title":"Targeting Protein Kinase CK1δ with Riluzole: Could It Be One of the Possible Missing Bricks to Interpret Its Effect in the Treatment of ALS from a Molecular Point of View?","journal":"ChemMedChem","work_id":53772,"publication_date":"2018-10-25"}],"source_paper_count":3,"extracted_claims":[{"side":"drug_mediator","object":"CK1δ","context":"in vitro biochemical assay","subject":"riluzole","work_id":52074,"claim_id":31981,"polarity":"positive","predicate":"inhibits","confidence":0.9,"extraction_run_id":15},{"side":"drug_mediator","object":"CK1δ","context":"in the treatment of ALS","subject":"Riluzole","work_id":53772,"claim_id":34940,"polarity":"positive","predicate":"inhibits","confidence":0.9,"extraction_run_id":15},{"side":"mediator_outcome","object":"pancreatic cancer","context":"in patient samples","subject":"CK1δ","work_id":177411,"claim_id":133726,"polarity":"positive","predicate":"associated_with","confidence":0.8,"extraction_run_id":23}],"extracted_claim_count":3,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[15,23]},"bridge":{"a_to_b_predicate":"inhibits","b_to_c_predicate":"associated_with","a_to_b_evidence_count":2,"b_to_c_evidence_count":1,"edge_support_log_ab":1.0986122886681098,"edge_support_log_bc":0.6931471805599453,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.1791759469228055,"score":0.26876392038420827,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:40.211207+00:00"}