{"schema_version":"1.0","hypothesis_id":7054,"triple":{"drug":"valproic acid","drug_canonical":"valproic acid","mediator":"HDAC3","mediator_canonical":"hdac3","outcome":"lymph node metastasis","outcome_canonical":"lymph node metastasis"},"domain":{"domain":"cross_domain","source":"epilepsy","target":"pancreatic_cancer"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.4103/0366-6999.239311","pmid":"30127218","year":2018,"roles":["drug_mediator"],"title":"Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice","journal":"Chin Med J (Engl)","work_id":128843,"publication_date":"2018-08-17"},{"doi":"10.3389/fnmol.2018.00117","pmid":"29719500","year":2018,"roles":["drug_mediator"],"title":"Valproic Acid Attenuates Traumatic Brain Injury-Induced Inflammation in Vivo: Involvement of Autophagy and the Nrf2/ARE Signaling Pathway","journal":"Front Mol Neurosci","work_id":30542,"publication_date":"2018-04-17"},{"doi":"10.1186/s12974-018-1193-6","pmid":"29776446","year":2018,"roles":["drug_mediator"],"title":"Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3","journal":"J Neuroinflammation","work_id":30081,"publication_date":"2018-05-18"},{"doi":"10.18632/oncotarget.7663","pmid":"26918727","year":2016,"roles":["mediator_outcome"],"title":"Aberrant expression of nuclear HDAC3 and cytoplasmic CDH1 predict a poor prognosis for patients with pancreatic cancer","journal":"Oncotarget","work_id":174873,"publication_date":"2016-02-24"}],"source_paper_count":4,"extracted_claims":[{"side":"drug_mediator","object":"HDAC3","context":"after spinal cord injury","subject":"Valproic acid","work_id":30081,"claim_id":12659,"polarity":"positive","predicate":"inhibits","confidence":0.9,"extraction_run_id":12},{"side":"drug_mediator","object":"HDAC3","context":"after TBI in vivo","subject":"Valproic Acid","work_id":30542,"claim_id":13480,"polarity":"positive","predicate":"inhibits","confidence":0.9,"extraction_run_id":13},{"side":"drug_mediator","object":"Hdac3","context":"in fetal hearts of mice","subject":"Valproic acid","work_id":128843,"claim_id":95510,"polarity":"positive","predicate":"downregulates","confidence":0.9,"extraction_run_id":20},{"side":"mediator_outcome","object":"lymph node metastasis","context":"pancreatic cancer patients","subject":"HDAC3","work_id":174873,"claim_id":128782,"polarity":"positive","predicate":"correlates_with","confidence":0.9,"extraction_run_id":23}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[12,13,20,23]},"bridge":{"a_to_b_predicate":"downregulates","b_to_c_predicate":"correlates_with","a_to_b_evidence_count":3,"b_to_c_evidence_count":1,"edge_support_log_ab":1.3862943611198906,"edge_support_log_bc":0.6931471805599453,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.20794415416798356,"score":0.3119162312519753,"quality_tier":"high","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:39.496175+00:00"}