{"schema_version":"1.0","hypothesis_id":6681,"triple":{"drug":"valproic acid","drug_canonical":"valproic acid","mediator":"histone deacetylase","mediator_canonical":"histone deacetylase","outcome":"amyotrophic lateral sclerosis","outcome_canonical":"amyotrophic lateral sclerosis"},"domain":{"domain":"cross_domain","source":"epilepsy","target":"als"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.31038/cst.2020511","pmid":"34621499","year":2020,"roles":["drug_mediator"],"title":"https://researchopenworld.com/the-addition-of-valproic-acid-to-concurrent-radiation-therapy-and-temozolomide-improves-patient-outcome-a-correlative-analysis-of-rtog-0525-seer-and-a-phase-ii-nci-trial/#","journal":"Cancer Stud Ther","work_id":127421,"publication_date":"2020-01-11"},{"doi":"10.1002/mus.26620","pmid":"31241177","year":2019,"roles":["mediator_outcome"],"title":"Class I and II histone deacetylase expression is not altered in human amyotrophic lateral sclerosis: Neuropathological and positron emission tomography molecular neuroimaging evidence","journal":"Muscle Nerve","work_id":135793,"publication_date":"2019-06-26"},{"doi":"10.1093/noajnl/vdz025","pmid":"32642660","year":2019,"roles":["drug_mediator"],"title":"Effects of valproic acid on histone deacetylase inhibition in vitro and in glioblastoma patient samples","journal":"Neurooncol Adv","work_id":126024,"publication_date":"2019-05-01"},{"doi":"10.1080/00498254.2019.1618510","pmid":"31092106","year":2019,"roles":["drug_mediator"],"title":"Metabolomics reveals the effect of valproic acid on MCF-7 and MDA-MB-231 cells","journal":"Xenobiotica","work_id":126001,"publication_date":"2019-05-16"},{"doi":"10.1016/j.jphs.2018.10.004","pmid":"30409713","year":2018,"roles":["drug_mediator"],"title":"Anti-angiogenic effects of valproic acid in a mouse model of oxygen-induced retinopathy","journal":"J Pharmacol Sci","work_id":125644,"publication_date":"2018-10-14"}],"source_paper_count":5,"extracted_claims":[{"side":"drug_mediator","object":"histone deacetylase","context":"in anti-angiogenic effects","subject":"valproic acid","work_id":125644,"claim_id":91159,"polarity":"positive","predicate":"inhibits","confidence":0.9,"extraction_run_id":20},{"side":"drug_mediator","object":"histone deacetylase","context":"in tumor therapy","subject":"valproic acid","work_id":126001,"claim_id":91707,"polarity":"positive","predicate":"inhibits","confidence":0.9,"extraction_run_id":20},{"side":"drug_mediator","object":"histone deacetylase","context":"in glioblastoma cells in vitro","subject":"valproic acid","work_id":126024,"claim_id":91747,"polarity":"positive","predicate":"inhibits","confidence":0.95,"extraction_run_id":20},{"side":"drug_mediator","object":"histone deacetylase","context":"","subject":"Valproic Acid","work_id":127421,"claim_id":93626,"polarity":"positive","predicate":"inhibits","confidence":0.9,"extraction_run_id":20},{"side":"mediator_outcome","object":"amyotrophic lateral sclerosis","context":"human brain tissue and in vivo PET imaging","subject":"histone deacetylase","work_id":135793,"claim_id":98837,"polarity":"negative","predicate":"correlates_with","confidence":0.9,"extraction_run_id":21}],"extracted_claim_count":5,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[20,21]},"bridge":{"a_to_b_predicate":"inhibits","b_to_c_predicate":"correlates_with","a_to_b_evidence_count":4,"b_to_c_evidence_count":1,"edge_support_log_ab":1.6094379124341003,"edge_support_log_bc":0.6931471805599453,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.23025850929940456,"score":0.34538776394910686,"quality_tier":"high","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:39.496175+00:00"}