{"schema_version":"1.0","hypothesis_id":5620,"triple":{"drug":"curcumin","drug_canonical":"curcumin","mediator":"MGMT","mediator_canonical":"mgmt","outcome":"seizure reduction","outcome_canonical":"seizure reduction"},"domain":{"domain":"cross_domain","source":"glioblastoma","target":"epilepsy"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1055/a-2800-2050","pmid":"41844218","year":2026,"roles":["drug_mediator"],"title":"Synergistic Effects of Curcumin and Temozolomide in Overcoming Glioblastoma Drug Resistance through Regulation of O6-Methylguanine-DNA Methyltransferase, Mismatch Repair, and Poly(Adenosine Diphosphate Ribose) Polymerase 1","journal":"Drug Res (Stuttg)","work_id":112095,"publication_date":"2026-03-17"},{"doi":"10.1080/00207454.2018.1555160","pmid":"30507318","year":2018,"roles":["mediator_outcome"],"title":"Perampanel in patients with brain tumor-related epilepsy in real-life clinical practice: a retrospective analysis","journal":"Int J Neurosci","work_id":117196,"publication_date":"2018-12-03"}],"source_paper_count":2,"extracted_claims":[{"side":"drug_mediator","object":"MGMT","context":"in U87 glioblastoma cells","subject":"curcumin","work_id":112095,"claim_id":87050,"polarity":"positive","predicate":"downregulates","confidence":0.9,"extraction_run_id":19},{"side":"mediator_outcome","object":"seizure reduction","context":"in glioma patients on perampanel","subject":"MGMT","work_id":117196,"claim_id":88480,"polarity":"negative","predicate":"correlates_with","confidence":0.7,"extraction_run_id":20}],"extracted_claim_count":2,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[19,20]},"bridge":{"a_to_b_predicate":"downregulates","b_to_c_predicate":"correlates_with","a_to_b_evidence_count":1,"b_to_c_evidence_count":1,"edge_support_log_ab":0.6931471805599453,"edge_support_log_bc":0.6931471805599453,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.13862943611198905,"score":0.20794415416798356,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:39.496175+00:00"}