{"schema_version":"1.0","hypothesis_id":5288,"triple":{"drug":"Glyphosate","drug_canonical":"glyphosate","mediator":"TP53","mediator_canonical":"TP53","outcome":"glioblastoma","outcome_canonical":"glioblastoma"},"domain":{"domain":"cross_domain","source":"depression","target":"glioblastoma"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1186/s12991-024-00491-4","pmid":"38297317","year":2024,"roles":["drug_mediator"],"title":"Clarification of the molecular mechanisms underlying glyphosate-induced major depressive disorder: a network toxicology approach","journal":"Ann Gen Psychiatry","work_id":79715,"publication_date":"2024-01-31"},{"doi":"10.3390/cancers16051046","pmid":"38473403","year":2024,"roles":["mediator_outcome"],"title":"Haploinsufficiency of Adenomatous Polyposis Coli Coupled with Kirsten Rat Sarcoma Viral Oncogene Homologue Activation and P53 Loss Provokes High-Grade Glioblastoma Formation in Mice","journal":"Cancers (Basel)","work_id":12069,"publication_date":"2024-03-04"},{"doi":"10.31557/apjcp.2024.25.11.4035","pmid":"39611928","year":2024,"roles":["mediator_outcome"],"title":"Bioinformatics Examination of Glioblastoma Identifies a Potential Panel of Therapeutic Biomarkers","journal":"Asian Pac J Cancer Prev","work_id":9016,"publication_date":"2024-11-01"},{"doi":"10.1007/s11060-023-04287-6","pmid":"37140883","year":2023,"roles":["mediator_outcome"],"title":"Genome-wide profiling of patient-derived glioblastoma stem-like cells reveals recurrent genetic and transcriptomic signatures associated with brain tumors","journal":"J Neurooncol","work_id":7313,"publication_date":"2023-05-01"}],"source_paper_count":4,"extracted_claims":[{"side":"drug_mediator","object":"TP53","context":"molecular docking","subject":"glyphosate","work_id":79715,"claim_id":79316,"polarity":"positive","predicate":"binds_to","confidence":0.9,"extraction_run_id":18},{"side":"mediator_outcome","object":"glioblastoma","context":"patient-derived glioblastoma stem-like cells","subject":"TP53","work_id":7313,"claim_id":8318,"polarity":"positive","predicate":"associated_with","confidence":0.9,"extraction_run_id":9},{"side":"mediator_outcome","object":"glioblastoma","context":"in glioblastoma tumor cells","subject":"TP53","work_id":9016,"claim_id":9471,"polarity":"positive","predicate":"associated_with","confidence":0.7,"extraction_run_id":9},{"side":"mediator_outcome","object":"glioblastoma","context":"human molecular pathology studies","subject":"TP53","work_id":12069,"claim_id":11369,"polarity":"positive","predicate":"associated_with","confidence":0.9,"extraction_run_id":9}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[9,18]},"bridge":{"a_to_b_predicate":"binds_to","b_to_c_predicate":"associated_with","a_to_b_evidence_count":1,"b_to_c_evidence_count":3,"edge_support_log_ab":0.6931471805599453,"edge_support_log_bc":1.3862943611198906,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.20794415416798356,"score":0.20794415416798356,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:39.496175+00:00"}