{"schema_version":"1.0","hypothesis_id":4385,"triple":{"drug":"ABC294640","drug_canonical":"abc294640","mediator":"RRM2","mediator_canonical":"RRM2","outcome":"glioblastoma","outcome_canonical":"glioblastoma"},"domain":{"domain":"cross_domain","source":"pancreatic_cancer","target":"glioblastoma"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.2174/0109298673316883240829073901","pmid":"39248068","year":2024,"roles":["mediator_outcome"],"title":"Bioinformatics Analysis Screening and Identification of Key Biomarkers and Drug Targets in Human Glioblastoma","journal":"Curr Med Chem","work_id":10811,"publication_date":"2024-09-09"},{"doi":"10.3389/fonc.2022.887294","pmid":"35651787","year":2022,"roles":["mediator_outcome"],"title":"RRM2 Mediates the Anti-Tumor Effect of the Natural Product Pectolinarigenin on Glioblastoma Through Promoting CDK1 Protein Degradation by Increasing Autophagic Flux","journal":"Front Oncol","work_id":3501,"publication_date":"2022-05-11"},{"doi":"10.1155/2019/6581576","pmid":"31119182","year":2019,"roles":["mediator_outcome"],"title":"Identification of Potential Biomarkers in Glioblastoma through Bioinformatic Analysis and Evaluating Their Prognostic Value","journal":"Biomed Res Int","work_id":374,"publication_date":"2019-04-15"},{"doi":"10.18632/oncotarget.11112","pmid":"27517489","year":2016,"roles":["drug_mediator"],"title":"Suppression of c-Myc and RRM2 expression in pancreatic cancer cells by the sphingosine kinase-2 inhibitor ABC294640","journal":"Oncotarget","work_id":74643,"publication_date":"2016-08-08"}],"source_paper_count":4,"extracted_claims":[{"side":"drug_mediator","object":"RRM2","context":"in human pancreatic cancer cell lines","subject":"ABC294640","work_id":74643,"claim_id":71438,"polarity":"positive","predicate":"downregulates","confidence":0.9,"extraction_run_id":17},{"side":"mediator_outcome","object":"glioblastoma","context":"bioinformatic analysis of TCGA and GEO datasets","subject":"RRM2","work_id":374,"claim_id":715,"polarity":"positive","predicate":"associated_with","confidence":0.8,"extraction_run_id":7},{"side":"mediator_outcome","object":"glioblastoma","context":"in GBM patients","subject":"RRM2","work_id":3501,"claim_id":4404,"polarity":"positive","predicate":"associated_with","confidence":0.8,"extraction_run_id":7},{"side":"mediator_outcome","object":"glioblastoma","context":"in glioblastoma patients from survival analysis","subject":"RRM2","work_id":10811,"claim_id":10853,"polarity":"positive","predicate":"associated_with","confidence":0.6,"extraction_run_id":9}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[7,9,17]},"bridge":{"a_to_b_predicate":"downregulates","b_to_c_predicate":"associated_with","a_to_b_evidence_count":1,"b_to_c_evidence_count":3,"edge_support_log_ab":0.6931471805599453,"edge_support_log_bc":1.3862943611198906,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.20794415416798356,"score":0.20794415416798356,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:39.496175+00:00"}