{"schema_version":"1.0","hypothesis_id":4177,"triple":{"drug":"GQ1b","drug_canonical":"gq1b","mediator":"BDNF","mediator_canonical":"BDNF","outcome":"schizophrenia","outcome_canonical":"schizophrenia"},"domain":{"domain":"cross_domain","source":"alzheimer","target":"depression"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1016/j.bbi.2021.07.009","pmid":"34280516","year":2021,"roles":["mediator_outcome"],"title":"Associations of immunological proteins/traits with schizophrenia, major depression and bipolar disorder: A bi-directional two-sample mendelian randomization study","journal":"Brain Behav Immun","work_id":76125,"publication_date":"2021-07-16"},{"doi":"10.1371/journal.pone.0212373","pmid":"30794585","year":2019,"roles":["mediator_outcome"],"title":"Accuracy of brain-derived neurotrophic factor levels for differentiating between Taiwanese patients with major depressive disorder or schizophrenia and healthy controls","journal":"PLoS One","work_id":80560,"publication_date":"2019-02-22"},{"doi":"10.1038/s41598-019-44739-6","pmid":"31186474","year":2019,"roles":["drug_mediator"],"title":"Ganglioside GQ1b ameliorates cognitive impairments in an Alzheimer’s disease mouse model, and causes reduction of amyloid precursor protein","journal":"Sci Rep","work_id":66025,"publication_date":"2019-06-11"}],"source_paper_count":3,"extracted_claims":[{"side":"drug_mediator","object":"BDNF","context":"in hippocampus of 3xTg-AD mice","subject":"GQ1b","work_id":66025,"claim_id":51131,"polarity":"positive","predicate":"upregulates","confidence":0.95,"extraction_run_id":16},{"side":"mediator_outcome","object":"schizophrenia","context":"Mendelian randomization analysis","subject":"BDNF","work_id":76125,"claim_id":75036,"polarity":"positive","predicate":"decreases","confidence":0.6,"extraction_run_id":18},{"side":"mediator_outcome","object":"schizophrenia","context":"serum levels in patients","subject":"BDNF","work_id":80560,"claim_id":80247,"polarity":"positive","predicate":"associated_with","confidence":0.9,"extraction_run_id":18},{"side":"mediator_outcome","object":"schizophrenia","context":"female patients","subject":"BDNF","work_id":80560,"claim_id":80250,"polarity":"positive","predicate":"predicts","confidence":0.7,"extraction_run_id":18}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[16,18]},"bridge":{"a_to_b_predicate":"upregulates","b_to_c_predicate":"decreases","a_to_b_evidence_count":1,"b_to_c_evidence_count":3,"edge_support_log_ab":0.6931471805599453,"edge_support_log_bc":1.3862943611198906,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.20794415416798356,"score":0.20794415416798356,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:39.496175+00:00"}