{"schema_version":"1.0","hypothesis_id":40798,"triple":{"drug":"exenatide","drug_canonical":"exenatide","mediator":"SIRT1","mediator_canonical":"SIRT1","outcome":"proliferation","outcome_canonical":null},"domain":{"domain":"cross_domain","source":"type_2_diabetes","target":"pancreatic_cancer"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1038/s41418-021-00821-z","pmid":"34163012","year":2021,"roles":["mediator_outcome"],"title":"SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis","journal":"Cell Death Differ","work_id":72034,"publication_date":"2021-06-23"},{"doi":"10.1002/hep.29238","pmid":"28439947","year":2017,"roles":["drug_mediator"],"title":"SIRT1/HSF1/HSP pathway is essential for exenatide‐alleviated, lipid‐induced hepatic endoplasmic reticulum stress","journal":"Hepatology","work_id":235313,"publication_date":"2017-04-25"},{"doi":"10.18632/oncotarget.11013","pmid":"27494892","year":2016,"roles":["mediator_outcome"],"title":"Sirtuin 1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions","journal":"Oncotarget","work_id":75030,"publication_date":"2016-08-02"},{"doi":null,"pmid":"26339397","year":2015,"roles":["drug_mediator"],"title":"Expression of SIRT1 in the ovaries of rats with polycystic ovary syndrome before and after therapeutic intervention with exenatide.","journal":"Int J Clin Exp Pathol","work_id":244400,"publication_date":"2015-01-01"}],"source_paper_count":4,"extracted_claims":[{"side":"drug_mediator","object":"SIRT1","context":"in hepatocytes","subject":"exenatide","work_id":235313,"claim_id":172811,"polarity":"positive","predicate":"activates","confidence":0.75,"extraction_run_id":27},{"side":"drug_mediator","object":"SIRT1","context":"rat ovary tissue","subject":"exenatide","work_id":244400,"claim_id":193265,"polarity":"positive","predicate":"upregulates","confidence":0.95,"extraction_run_id":27},{"side":"mediator_outcome","object":"proliferation","context":"pancreatic cancer cells","subject":"SIRT1","work_id":72034,"claim_id":64499,"polarity":"positive","predicate":"increases","confidence":0.8,"extraction_run_id":17},{"side":"mediator_outcome","object":"proliferation","context":"in pancreatic neoplastic lesions (KC;Sirt1-lox mice and human PDAC cell line)","subject":"SIRT1","work_id":75030,"claim_id":72492,"polarity":"positive","predicate":"increases","confidence":0.9,"extraction_run_id":17}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[17,27]},"bridge":{"a_to_b_predicate":"upregulates","b_to_c_predicate":"increases","a_to_b_evidence_count":2,"b_to_c_evidence_count":2,"edge_support_log_ab":1.0986122886681098,"edge_support_log_bc":1.0986122886681098,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.21972245773362195,"score":0.21972245773362195,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:41.695630+00:00"}