{"schema_version":"1.0","hypothesis_id":40783,"triple":{"drug":"liraglutide","drug_canonical":"liraglutide","mediator":"Akt","mediator_canonical":"akt","outcome":"spheroid growth","outcome_canonical":"spheroid growth"},"domain":{"domain":"cross_domain","source":"type_2_diabetes","target":"pancreatic_cancer"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.14715/cmb/2023.69.14.37","pmid":"38279433","year":2023,"roles":["drug_mediator"],"title":"GLP-1 receptor agonist liraglutide inhibits the proliferation and migration of thyroid cancer cells","journal":"Cell Mol Biol (Noisy-le-grand)","work_id":240596,"publication_date":"2023-12-20"},{"doi":"10.1186/s12933-022-01486-9","pmid":"35397526","year":2022,"roles":["drug_mediator"],"title":"Liraglutide preserves CD34+ stem cells from dysfunction Induced by high glucose exposure","journal":"Cardiovasc Diabetol","work_id":239446,"publication_date":"2022-04-09"},{"doi":"10.1002/ijc.34367","pmid":"36408933","year":2022,"roles":["mediator_outcome"],"title":"Crosstalk between tumor acidosis, p53 and extracellular matrix regulates pancreatic cancer aggressiveness","journal":"Int J Cancer","work_id":75865,"publication_date":"2022-11-21"},{"doi":"10.14348/molcells.2018.2340","pmid":"29463067","year":2018,"roles":["drug_mediator"],"title":"Liraglutide Inhibits the Apoptosis of MC3T3-E1 Cells Induced by Serum Deprivation through cAMP/PKA/β-Catenin and PI3K/AKT/GSK3β Signaling Pathways.","journal":"Mol Cells","work_id":246984,"publication_date":"2018-03-31"},{"doi":"10.1111/jcmm.13259","pmid":"29524296","year":2018,"roles":["drug_mediator"],"title":"Liraglutide, a human glucagon‐like peptide‐1 analogue, stimulates AKT‐dependent survival signalling and inhibits pancreatic β‐cell apoptosis","journal":"J Cell Mol Med","work_id":243085,"publication_date":"2018-03-10"},{"doi":"10.3233/jad-143150","pmid":"25624414","year":2015,"roles":["drug_mediator"],"title":"Anorexigenic Lipopeptides Ameliorate Central Insulin Signaling and Attenuate Tau Phosphorylation in Hippocampi of Mice with Monosodium Glutamate-Induced Obesity","journal":"J Alzheimers Dis","work_id":244685,"publication_date":"2015-03-24"},{"doi":"10.1111/jnc.13248","pmid":"26183127","year":2015,"roles":["drug_mediator"],"title":"Early intervention with glucagon‐like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice","journal":"J Neurochem","work_id":242949,"publication_date":"2015-07-16"}],"source_paper_count":7,"extracted_claims":[{"side":"drug_mediator","object":"AKT","context":"in CD34+ stem cells","subject":"Liraglutide","work_id":239446,"claim_id":182346,"polarity":"positive","predicate":"activates","confidence":0.9,"extraction_run_id":27},{"side":"drug_mediator","object":"Akt","context":"in thyroid cancer cells","subject":"liraglutide","work_id":240596,"claim_id":184825,"polarity":"positive","predicate":"downregulates","confidence":0.85,"extraction_run_id":27},{"side":"drug_mediator","object":"Akt","context":"in hippocampal formation of db/db mice","subject":"liraglutide","work_id":242949,"claim_id":190033,"polarity":"positive","predicate":"activates","confidence":0.7,"extraction_run_id":27},{"side":"drug_mediator","object":"AKT","context":"in βTC-6 cells via PI3-kinase-dependent signalling","subject":"liraglutide","work_id":243085,"claim_id":190374,"polarity":"positive","predicate":"activates","confidence":0.85,"extraction_run_id":27},{"side":"drug_mediator","object":"Akt","context":"in hippocampus of 6-month-old MSG-obese mice after 2 weeks subcutaneous treatment","subject":"liraglutide","work_id":244685,"claim_id":194023,"polarity":"positive","predicate":"activates","confidence":0.85,"extraction_run_id":27},{"side":"drug_mediator","object":"AKT","context":"in MC3T3-E1 cells via phosphorylation","subject":"liraglutide","work_id":246984,"claim_id":199091,"polarity":"positive","predicate":"activates","confidence":0.85,"extraction_run_id":27},{"side":"mediator_outcome","object":"spheroid growth","context":"in PDAC spheroids","subject":"Akt","work_id":75865,"claim_id":74473,"polarity":"positive","predicate":"increases","confidence":0.7,"extraction_run_id":17}],"extracted_claim_count":7,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[17,27]},"bridge":{"a_to_b_predicate":"activates","b_to_c_predicate":"increases","a_to_b_evidence_count":6,"b_to_c_evidence_count":1,"edge_support_log_ab":1.9459101490553132,"edge_support_log_bc":0.6931471805599453,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.26390573296152586,"score":0.26390573296152586,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:41.695630+00:00"}