{"schema_version":"1.0","hypothesis_id":40425,"triple":{"drug":"exenatide","drug_canonical":"exenatide","mediator":"AMPK","mediator_canonical":"AMPK","outcome":"intestinal inflammation","outcome_canonical":"intestinal inflammation"},"domain":{"domain":"cross_domain","source":"type_2_diabetes","target":"inflammatory_bowel_disease"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1093/ibd/izaa305","pmid":"33252129","year":2020,"roles":["mediator_outcome"],"title":"Salicylates Ameliorate Intestinal Inflammation by Activating Macrophage AMPK","journal":"Inflamm Bowel Dis","work_id":269650,"publication_date":"2020-11-30"},{"doi":"10.1002/jcp.30102","pmid":"33044023","year":2020,"roles":["drug_mediator"],"title":"Exenatide improves random‐pattern skin flap survival via TFE3 mediated autophagy augment","journal":"J Cell Physiol","work_id":249723,"publication_date":"2020-10-12"},{"doi":"10.1186/s12967-016-0985-7","pmid":"27473212","year":2016,"roles":["drug_mediator"],"title":"The GLP-1 receptor agonists exenatide and liraglutide activate Glucose transport by an AMPK-dependent mechanism","journal":"J Transl Med","work_id":234537,"publication_date":"2016-07-30"},{"doi":"10.2337/db14-0976","pmid":"25720388","year":2015,"roles":["drug_mediator"],"title":"Exenatide Protects Against Glucose- and Lipid-Induced Endothelial Dysfunction: Evidence for Direct Vasodilation Effect of GLP-1 Receptor Agonists in Humans","journal":"Diabetes","work_id":233012,"publication_date":"2015-02-26"}],"source_paper_count":4,"extracted_claims":[{"side":"drug_mediator","object":"AMPK","context":"in human arterioles and endothelial cells","subject":"exenatide","work_id":233012,"claim_id":166856,"polarity":"positive","predicate":"activates","confidence":0.7,"extraction_run_id":27},{"side":"drug_mediator","object":"AMPK","context":"in L6 myotubes","subject":"exenatide","work_id":234537,"claim_id":170794,"polarity":"positive","predicate":"activates","confidence":0.85,"extraction_run_id":27},{"side":"drug_mediator","object":"AMPK","context":"in random-pattern skin flap model","subject":"Exenatide","work_id":249723,"claim_id":205151,"polarity":"positive","predicate":"activates","confidence":0.7,"extraction_run_id":27},{"side":"mediator_outcome","object":"intestinal inflammation","context":"in DSS-induced colitis model","subject":"AMPK","work_id":269650,"claim_id":218590,"polarity":"positive","predicate":"treats","confidence":0.8,"extraction_run_id":31}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[27,31]},"bridge":{"a_to_b_predicate":"activates","b_to_c_predicate":"treats","a_to_b_evidence_count":3,"b_to_c_evidence_count":1,"edge_support_log_ab":1.3862943611198906,"edge_support_log_bc":0.6931471805599453,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.20794415416798356,"score":0.20794415416798356,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:41.695630+00:00"}