{"schema_version":"1.0","hypothesis_id":39636,"triple":{"drug":"resveratrol","drug_canonical":"resveratrol","mediator":"SIRT1","mediator_canonical":"SIRT1","outcome":"Aβ-induced neurotoxicity","outcome_canonical":"aβ-induced neurotoxicity"},"domain":{"domain":"cross_domain","source":"type_2_diabetes","target":"alzheimer"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1111/acel.13967","pmid":"37602729","year":2023,"roles":["mediator_outcome"],"title":"Cooperative effects of <scp>SIRT1</scp> and <scp>SIRT2</scp> on <scp>APP</scp> acetylation","journal":"Aging Cell","work_id":67422,"publication_date":"2023-08-21"},{"doi":"10.1111/andr.12891","pmid":"32808479","year":2020,"roles":["drug_mediator"],"title":"Resveratrol improves sperm DNA quality and reproductive capacity in type 1 diabetes","journal":"Andrology","work_id":247014,"publication_date":"2020-08-27"},{"doi":"10.3390/nu11010105","pmid":"30621358","year":2019,"roles":["drug_mediator"],"title":"Protective Effect of Resveratrol against Ischemia-Reperfusion Injury via Enhanced High Energy Compounds and eNOS-SIRT1 Expression in Type 2 Diabetic Female Rat Heart","journal":"Nutrients","work_id":243039,"publication_date":"2019-01-06"},{"doi":"10.1039/c9fo01075k","pmid":"31486447","year":2019,"roles":["drug_mediator"],"title":"The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease","journal":"Food Funct","work_id":233002,"publication_date":"2019-01-01"}],"source_paper_count":4,"extracted_claims":[{"side":"drug_mediator","object":"SIRT1","context":"in PBMCs of T2DM patients with CHD","subject":"resveratrol","work_id":233002,"claim_id":166800,"polarity":"positive","predicate":"upregulates","confidence":0.9,"extraction_run_id":27},{"side":"drug_mediator","object":"SIRT1","context":"in GK rat hearts","subject":"Resveratrol","work_id":243039,"claim_id":190273,"polarity":"positive","predicate":"upregulates","confidence":0.8,"extraction_run_id":27},{"side":"drug_mediator","object":"SIRT1","context":"in diabetic male rats","subject":"Resveratrol","work_id":247014,"claim_id":199146,"polarity":"positive","predicate":"activates","confidence":0.7,"extraction_run_id":27},{"side":"mediator_outcome","object":"Aβ-induced neurotoxicity","context":"in HT22 mouse hippocampal neuronal cells","subject":"SIRT1","work_id":67422,"claim_id":54175,"polarity":"positive","predicate":"prevents","confidence":0.9,"extraction_run_id":16}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[16,27]},"bridge":{"a_to_b_predicate":"activates","b_to_c_predicate":"prevents","a_to_b_evidence_count":3,"b_to_c_evidence_count":1,"edge_support_log_ab":1.3862943611198906,"edge_support_log_bc":0.6931471805599453,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.20794415416798356,"score":0.3119162312519753,"quality_tier":"high","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:40.945575+00:00"}