{"schema_version":"1.0","hypothesis_id":39634,"triple":{"drug":"bromophenols","drug_canonical":"bromophenols","mediator":"SIRT1","mediator_canonical":"SIRT1","outcome":"Alzheimer's disease","outcome_canonical":"Alzheimer disease"},"domain":{"domain":"cross_domain","source":"type_2_diabetes","target":"alzheimer"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1186/s13098-025-01981-5","pmid":"41094589","year":2025,"roles":["drug_mediator"],"title":"Marine nutraceuticals as a source of SIRT1 and NRF2 activators for diabetes and aging-related metabolic disorders","journal":"Diabetol Metab Syndr","work_id":242206,"publication_date":"2025-10-16"},{"doi":"10.18632/aging.205015","pmid":"37742223","year":2023,"roles":["mediator_outcome"],"title":"Serum sirtuin1: a potential blood biomarker for early diagnosis of Alzheimer’s disease","journal":"Aging (Albany NY)","work_id":68137,"publication_date":"2023-09-22"},{"doi":"10.18632/aging.101564","pmid":"30243024","year":2018,"roles":["mediator_outcome"],"title":"Sirt1 enhances tau exon 10 inclusion and improves spatial memory of Htau mice","journal":"Aging (Albany NY)","work_id":160396,"publication_date":"2018-09-22"}],"source_paper_count":3,"extracted_claims":[{"side":"drug_mediator","object":"SIRT1","context":"in marine nutraceuticals for diabetes and aging-related metabolic disorders","subject":"bromophenols","work_id":242206,"claim_id":188083,"polarity":"positive","predicate":"activates","confidence":0.7,"extraction_run_id":27},{"side":"mediator_outcome","object":"Alzheimer's disease","context":"serum samples from Alzheimer's disease patients, mild cognitive impairment patients, and normal controls","subject":"SIRT1","work_id":68137,"claim_id":55629,"polarity":"positive","predicate":"predicts","confidence":0.9,"extraction_run_id":16},{"side":"mediator_outcome","object":"Alzheimer's disease","context":"early diagnosis using serum biomarker","subject":"SIRT1","work_id":68137,"claim_id":55630,"polarity":"positive","predicate":"associated_with","confidence":0.85,"extraction_run_id":16},{"side":"mediator_outcome","object":"Alzheimer's disease","context":"general","subject":"Sirt1","work_id":160396,"claim_id":113454,"polarity":"positive","predicate":"associated_with","confidence":0.7,"extraction_run_id":22}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[16,22,27]},"bridge":{"a_to_b_predicate":"activates","b_to_c_predicate":"predicts","a_to_b_evidence_count":1,"b_to_c_evidence_count":3,"edge_support_log_ab":0.6931471805599453,"edge_support_log_bc":1.3862943611198906,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.20794415416798356,"score":0.20794415416798356,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:40.945575+00:00"}