{"schema_version":"1.0","hypothesis_id":39053,"triple":{"drug":"namilumab","drug_canonical":"namilumab","mediator":"GM-CSF","mediator_canonical":"gm-csf","outcome":"cachexia","outcome_canonical":"cachexia"},"domain":{"domain":"cross_domain","source":"rheumatoid_arthritis","target":"pancreatic_cancer"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1186/s13075-019-1879-x","pmid":"30999929","year":2019,"roles":["drug_mediator"],"title":"Efficacy and safety of namilumab, a human monoclonal antibody against granulocyte-macrophage colony-stimulating factor (GM-CSF) ligand in patients with rheumatoid arthritis (RA) with either an inadequate response to background methotrexate therapy or an inadequate response or intolerance to an anti-TNF (tumour necrosis factor) biologic therapy: a randomized, controlled trial","journal":"Arthritis Res Ther","work_id":286396,"publication_date":"2019-04-18"},{"doi":"10.5414/cp203235","pmid":"30168415","year":2018,"roles":["drug_mediator"],"title":"Randomized, double-blind, placebo-controlled, phase I study of the safety and pharmacokinetics of namilumab in healthy Japanese and Caucasian men","journal":"Int J Clin Pharmacol Ther","work_id":300854,"publication_date":"2018-08-31"},{"doi":"10.1002/jcsm.12251","pmid":"29316343","year":2018,"roles":["mediator_outcome"],"title":"Circulating monocyte chemoattractant protein‐1 (MCP‐1) is associated with cachexia in treatment‐naïve pancreatic cancer patients","journal":"J Cachexia Sarcopenia Muscle","work_id":70920,"publication_date":"2018-01-07"}],"source_paper_count":3,"extracted_claims":[{"side":"drug_mediator","object":"GM-CSF","context":"in vitro","subject":"namilumab","work_id":286396,"claim_id":207192,"polarity":"positive","predicate":"binds_to","confidence":0.95,"extraction_run_id":29},{"side":"drug_mediator","object":"GM-CSF","context":"in rheumatoid arthritis patients","subject":"namilumab","work_id":286396,"claim_id":207193,"polarity":"positive","predicate":"inhibits","confidence":0.7,"extraction_run_id":29},{"side":"drug_mediator","object":"GM-CSF","context":"in healthy Japanese and Caucasian men","subject":"namilumab","work_id":300854,"claim_id":257859,"polarity":"positive","predicate":"binds_to","confidence":0.8,"extraction_run_id":29},{"side":"mediator_outcome","object":"cachexia","context":"decreased levels in treatment-naïve cachectic patients, confounded by BMI","subject":"GM-CSF","work_id":70920,"claim_id":61525,"polarity":"positive","predicate":"correlates_with","confidence":0.7,"extraction_run_id":17}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[17,29]},"bridge":{"a_to_b_predicate":"binds_to","b_to_c_predicate":"correlates_with","a_to_b_evidence_count":3,"b_to_c_evidence_count":1,"edge_support_log_ab":1.3862943611198906,"edge_support_log_bc":0.6931471805599453,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.20794415416798356,"score":0.20794415416798356,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:40.945575+00:00"}