{"schema_version":"1.0","hypothesis_id":37866,"triple":{"drug":"NBTL","drug_canonical":"nbtl","mediator":"MAPT","mediator_canonical":"MAPT","outcome":"Alzheimer's disease","outcome_canonical":"Alzheimer disease"},"domain":{"domain":"cross_domain","source":"rheumatoid_arthritis","target":"alzheimer"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1007/s10571-025-01655-w","pmid":"41634510","year":2026,"roles":["mediator_outcome"],"title":"The 3xTg-AD Mouse Model: A Comprehensive Tool for Understanding Alzheimer’s Disease","journal":"Cell Mol Neurobiol","work_id":160285,"publication_date":"2026-02-03"},{"doi":"10.2147/jir.s557354","pmid":"41234504","year":2025,"roles":["drug_mediator"],"title":"New Bitongling Ameliorates Joint Tissue Damage in Collagen-Induced Arthritis Mice by Suppressing Mapt Expression: A Genome-Wide Sequencing Study","journal":"J Inflamm Res","work_id":294125,"publication_date":"2025-11-01"},{"doi":"10.1007/s12035-020-02258-w","pmid":"33415685","year":2021,"roles":["mediator_outcome"],"title":"Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration","journal":"Mol Neurobiol","work_id":156466,"publication_date":"2021-01-07"},{"doi":"10.1038/s41598-019-44848-2","pmid":"31182772","year":2019,"roles":["mediator_outcome"],"title":"Genetic analyses of early-onset Alzheimer’s disease using next generation sequencing","journal":"Sci Rep","work_id":60582,"publication_date":"2019-06-10"},{"doi":"10.1002/prca.201800105","pmid":"30578620","year":2018,"roles":["mediator_outcome"],"title":"Quantitative Proteomic Profiling of Cerebrospinal Fluid to Identify Candidate Biomarkers for Alzheimer's Disease","journal":"Proteomics Clin Appl","work_id":60649,"publication_date":"2018-12-22"}],"source_paper_count":5,"extracted_claims":[{"side":"drug_mediator","object":"Mapt","context":"in collagen-induced arthritis mice","subject":"NBTL","work_id":294125,"claim_id":236647,"polarity":"positive","predicate":"suppresses","confidence":0.9,"extraction_run_id":29},{"side":"mediator_outcome","object":"Alzheimer's disease","context":"in Korean early-onset Alzheimer's disease patients","subject":"MAPT","work_id":60582,"claim_id":38172,"polarity":"positive","predicate":"associated_with","confidence":0.6,"extraction_run_id":16},{"side":"mediator_outcome","object":"Alzheimer's disease","context":"in CSF of AD patients","subject":"MAPT","work_id":60649,"claim_id":38337,"polarity":"positive","predicate":"associated_with","confidence":0.8,"extraction_run_id":16},{"side":"mediator_outcome","object":"Alzheimer's disease","context":"in induced neurons from porcine and murine cerebral cortices","subject":"MAPT","work_id":156466,"claim_id":106751,"polarity":"positive","predicate":"associated_with","confidence":0.6,"extraction_run_id":22},{"side":"mediator_outcome","object":"Alzheimer's disease","context":"in humans","subject":"MAPT","work_id":160285,"claim_id":113191,"polarity":"positive","predicate":"associated_with","confidence":0.8,"extraction_run_id":22}],"extracted_claim_count":5,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[16,22,29]},"bridge":{"a_to_b_predicate":"suppresses","b_to_c_predicate":"associated_with","a_to_b_evidence_count":1,"b_to_c_evidence_count":4,"edge_support_log_ab":0.6931471805599453,"edge_support_log_bc":1.6094379124341003,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.23025850929940456,"score":0.23025850929940456,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:40.945575+00:00"}