{"schema_version":"1.0","hypothesis_id":37705,"triple":{"drug":"chelerythrine","drug_canonical":"chelerythrine","mediator":"TDP-43","mediator_canonical":"TDP-43","outcome":"FTLD","outcome_canonical":"ftld"},"domain":{"domain":"cross_domain","source":"rheumatoid_arthritis","target":"als"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.2174/0118715273374466250617085832","pmid":"40619651","year":2025,"roles":["mediator_outcome"],"title":"TDP-43 Proteinopathies in ALS and FTLD: Mechanistic Insights andTherapeutic Approaches","journal":"CNS Neurol Disord Drug Targets","work_id":136802,"publication_date":"2025-07-03"},{"doi":"10.1021/acs.biochem.9b00592","pmid":"31529970","year":2019,"roles":["mediator_outcome"],"title":"Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis","journal":"Biochemistry","work_id":54135,"publication_date":"2019-09-06"},{"doi":"10.1038/s41598-018-20565-0","pmid":"29396541","year":2018,"roles":["drug_mediator"],"title":"TDP-43 self-interaction is modulated by redox-active compounds Auranofin, Chelerythrine and Riluzole","journal":"Sci Rep","work_id":289068,"publication_date":"2018-01-29"},{"doi":null,"pmid":"26689008","year":2015,"roles":["mediator_outcome"],"title":"[RNA processing TDP-43 protein has a main pathological role in FTLD and ALS].","journal":"Postepy Biochem","work_id":140052,"publication_date":"2015-01-01"}],"source_paper_count":4,"extracted_claims":[{"side":"drug_mediator","object":"TDP-43","context":"self-interaction","subject":"chelerythrine","work_id":289068,"claim_id":216270,"polarity":"positive","predicate":"inhibits","confidence":0.95,"extraction_run_id":29},{"side":"mediator_outcome","object":"FTLD","context":"as major constituent of proteinaceous inclusions","subject":"TDP-43","work_id":54135,"claim_id":35516,"polarity":"positive","predicate":"associated_with","confidence":0.95,"extraction_run_id":15},{"side":"mediator_outcome","object":"FTLD","context":"in ALS and FTLD","subject":"TDP-43","work_id":136802,"claim_id":99138,"polarity":"positive","predicate":"associated_with","confidence":0.9,"extraction_run_id":21},{"side":"mediator_outcome","object":"FTLD","context":"in Frontotemporal Lobar Degeneration cases","subject":"TDP-43","work_id":140052,"claim_id":101701,"polarity":"positive","predicate":"associated_with","confidence":0.9,"extraction_run_id":21}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[15,21,29]},"bridge":{"a_to_b_predicate":"inhibits","b_to_c_predicate":"associated_with","a_to_b_evidence_count":1,"b_to_c_evidence_count":3,"edge_support_log_ab":0.6931471805599453,"edge_support_log_bc":1.3862943611198906,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.20794415416798356,"score":0.20794415416798356,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:40.945575+00:00"}