{"schema_version":"1.0","hypothesis_id":37668,"triple":{"drug":"baricitinib","drug_canonical":"baricitinib","mediator":"MCP-1","mediator_canonical":"mcp-1","outcome":"ALS","outcome_canonical":"amyotrophic lateral sclerosis"},"domain":{"domain":"cross_domain","source":"rheumatoid_arthritis","target":"als"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1080/21678421.2026.2627902","pmid":"41689476","year":2026,"roles":["mediator_outcome"],"title":"Systemic immune-metabolic interactions in patients with amyotrophic lateral sclerosis: correlations of plasma cytokines with metabolic status","journal":"Amyotroph Lateral Scler Frontotemporal Degener","work_id":137076,"publication_date":"2026-02-14"},{"doi":"10.55563/clinexprheumatol/cfsajk","pmid":"34665696","year":2020,"roles":["drug_mediator"],"title":"The JAK inhibitor baricitinib inhibits oncostatin M induction of proinflammatory mediators in ex-vivo synovial derived cells","journal":"Clin Exp Rheumatol","work_id":295189,"publication_date":"2020-12-02"},{"doi":"10.1002/acn3.51078","pmid":"32515902","year":2020,"roles":["mediator_outcome"],"title":"Longitudinal biomarkers in amyotrophic lateral sclerosis","journal":"Ann Clin Transl Neurol","work_id":50336,"publication_date":"2020-06-09"}],"source_paper_count":3,"extracted_claims":[{"side":"drug_mediator","object":"MCP-1","context":"in RA synovial fibroblasts stimulated with OSM","subject":"baricitinib","work_id":295189,"claim_id":240628,"polarity":"positive","predicate":"suppresses","confidence":0.95,"extraction_run_id":29},{"side":"drug_mediator","object":"MCP-1","context":"in human foreskin fibroblasts (HSF) stimulated with TNFα","subject":"baricitinib","work_id":295189,"claim_id":240630,"polarity":"positive","predicate":"inhibits","confidence":0.9,"extraction_run_id":29},{"side":"mediator_outcome","object":"ALS","context":"in plasma and cerebrospinal fluid of ALS patients compared to controls","subject":"MCP-1","work_id":50336,"claim_id":28185,"polarity":"positive","predicate":"associated_with","confidence":0.9,"extraction_run_id":15},{"side":"mediator_outcome","object":"ALS","context":"plasma from ALS patients compared to controls","subject":"MCP-1","work_id":137076,"claim_id":99573,"polarity":"positive","predicate":"associated_with","confidence":0.7,"extraction_run_id":21}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[15,21,29]},"bridge":{"a_to_b_predicate":"inhibits","b_to_c_predicate":"associated_with","a_to_b_evidence_count":2,"b_to_c_evidence_count":2,"edge_support_log_ab":1.0986122886681098,"edge_support_log_bc":1.0986122886681098,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.21972245773362195,"score":0.21972245773362195,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:40.945575+00:00"}