{"schema_version":"1.0","hypothesis_id":35507,"triple":{"drug":"Stattic","drug_canonical":"stattic","mediator":"IL-17A","mediator_canonical":"il-17a","outcome":"rheumatoid arthritis","outcome_canonical":"rheumatoid arthritis"},"domain":{"domain":"cross_domain","source":"multiple_sclerosis","target":"rheumatoid_arthritis"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1186/s12920-023-01713-6","pmid":"37926850","year":2023,"roles":["mediator_outcome"],"title":"Genetic association between interleukin-17 and susceptibility to rheumatoid arthritis","journal":"BMC Med Genomics","work_id":297599,"publication_date":"2023-11-06"},{"doi":"10.1038/s41598-021-94841-x","pmid":"34321563","year":2021,"roles":["mediator_outcome"],"title":"The role of IL-18 in addition to Th17 cytokines in rheumatoid arthritis development and treatment in women","journal":"Sci Rep","work_id":289865,"publication_date":"2021-07-28"},{"doi":"10.3390/pharmaceutics13070925","pmid":"34206429","year":2021,"roles":["drug_mediator"],"title":"Pharmacological Inhibition of STAT3 by Stattic Ameliorates Clinical Symptoms and Reduces Autoinflammation in Myeloid, Lymphoid, and Neuronal Tissue Compartments in Relapsing–Remitting Model of Experimental Autoimmune Encephalomyelitis in SJL/J Mice","journal":"Pharmaceutics","work_id":197251,"publication_date":"2021-06-22"},{"doi":"10.1111/sji.12872","pmid":"32048307","year":2020,"roles":["mediator_outcome"],"title":"The prostaglandin E2 increases the production of IL‐17 and the expression of costimulatory molecules on γδ T cells in rheumatoid arthritis","journal":"Scand J Immunol","work_id":295283,"publication_date":"2020-02-12"}],"source_paper_count":4,"extracted_claims":[{"side":"drug_mediator","object":"IL-17A","context":"in CD4+ T cells of EAE SJL/J mice","subject":"Stattic","work_id":197251,"claim_id":142754,"polarity":"positive","predicate":"downregulates","confidence":0.9,"extraction_run_id":25},{"side":"mediator_outcome","object":"rheumatoid arthritis","context":"in female RA patients","subject":"IL-17A","work_id":289865,"claim_id":219762,"polarity":"positive","predicate":"associated_with","confidence":0.95,"extraction_run_id":29},{"side":"mediator_outcome","object":"rheumatoid arthritis","context":"in patients with RA compared to healthy controls","subject":"IL-17A","work_id":295283,"claim_id":240998,"polarity":"positive","predicate":"associated_with","confidence":0.9,"extraction_run_id":29},{"side":"mediator_outcome","object":"rheumatoid arthritis","context":"in two-sample Mendelian randomization analysis","subject":"IL-17A","work_id":297599,"claim_id":247306,"polarity":"positive","predicate":"increases","confidence":0.9,"extraction_run_id":29}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[25,29]},"bridge":{"a_to_b_predicate":"downregulates","b_to_c_predicate":"associated_with","a_to_b_evidence_count":1,"b_to_c_evidence_count":3,"edge_support_log_ab":0.6931471805599453,"edge_support_log_bc":1.3862943611198906,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.20794415416798356,"score":0.20794415416798356,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:40.945575+00:00"}