{"schema_version":"1.0","hypothesis_id":35085,"triple":{"drug":"nivolumab","drug_canonical":"nivolumab","mediator":"PD-1","mediator_canonical":"pd-1","outcome":"PD-1 inhibitor-associated colitis","outcome_canonical":"pd-1 inhibitor-associated colitis"},"domain":{"domain":"cross_domain","source":"multiple_sclerosis","target":"inflammatory_bowel_disease"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1002/1545-5017.70262","pmid":"41846303","year":2026,"roles":["drug_mediator"],"title":"Nivolumab‐Associated Autoimmune Encephalopathy in a Child With Multiply Relapsed Anaplastic Ependymoma","journal":"Pediatr Blood Cancer","work_id":209398,"publication_date":"2026-03-17"},{"doi":"10.1111/his.14115","pmid":"32298485","year":2020,"roles":["mediator_outcome"],"title":"Programmed cell death‐1 (PD‐1) and programmed death‐ligand 1 (PD‐L1) expression in PD‐1 inhibitor‐associated colitis and its mimics","journal":"Histopathology","work_id":274678,"publication_date":"2020-04-16"},{"doi":"10.1097/cnd.0000000000000230","pmid":"31135622","year":2019,"roles":["drug_mediator"],"title":"Severe Relapse of Vaccine-Induced Guillain–Barré Syndrome After Treatment With Nivolumab","journal":"J Clin Neuromuscul Dis","work_id":200030,"publication_date":"2019-05-25"},{"doi":"10.1212/nxi.0000000000000439","pmid":"30465016","year":2018,"roles":["drug_mediator"],"title":"Natalizumab may control immune checkpoint inhibitor–induced limbic encephalitis","journal":"Neurol Neuroimmunol Neuroinflamm","work_id":196225,"publication_date":"2018-01-13"}],"source_paper_count":4,"extracted_claims":[{"side":"drug_mediator","object":"PD-1","context":"in cancer immunotherapy","subject":"nivolumab","work_id":196225,"claim_id":140868,"polarity":"positive","predicate":"inhibits","confidence":0.9,"extraction_run_id":25},{"side":"drug_mediator","object":"PD-1","context":"as a monoclonal antibody","subject":"nivolumab","work_id":200030,"claim_id":147539,"polarity":"positive","predicate":"binds_to","confidence":1.0,"extraction_run_id":25},{"side":"drug_mediator","object":"PD-1","context":"general","subject":"Nivolumab","work_id":209398,"claim_id":160038,"polarity":"positive","predicate":"inhibits","confidence":0.9,"extraction_run_id":25},{"side":"mediator_outcome","object":"PD-1 inhibitor-associated colitis","context":"in inflammatory cells","subject":"PD-1","work_id":274678,"claim_id":240924,"polarity":"positive","predicate":"decreases","confidence":0.85,"extraction_run_id":31}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[25,31]},"bridge":{"a_to_b_predicate":"inhibits","b_to_c_predicate":"decreases","a_to_b_evidence_count":3,"b_to_c_evidence_count":1,"edge_support_log_ab":1.3862943611198906,"edge_support_log_bc":0.6931471805599453,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.20794415416798356,"score":0.20794415416798356,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:40.945575+00:00"}