{"schema_version":"1.0","hypothesis_id":33008,"triple":{"drug":"metformin","drug_canonical":"metformin","mediator":"IL-17","mediator_canonical":"il-17","outcome":"idiopathic epilepsy","outcome_canonical":"idiopathic epilepsy"},"domain":{"domain":"cross_domain","source":"inflammatory_bowel_disease","target":"epilepsy"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1371/journal.pone.0262285","pmid":"35025939","year":2022,"roles":["mediator_outcome"],"title":"Th17 cell-mediated immune response in a subpopulation of dogs with idiopathic epilepsy","journal":"PLoS One","work_id":40166,"publication_date":"2022-01-13"},{"doi":"10.1080/10520295.2020.1776896","pmid":"32654569","year":2020,"roles":["drug_mediator"],"title":"Metformin alleviates experimental colitis in mice by up-regulating TGF-β signaling","journal":"Biotech Histochem","work_id":270824,"publication_date":"2020-07-13"},{"doi":"10.1371/journal.pone.0135858","pmid":"26360050","year":2015,"roles":["drug_mediator"],"title":"Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance","journal":"PLoS One","work_id":268113,"publication_date":"2015-09-11"}],"source_paper_count":3,"extracted_claims":[{"side":"drug_mediator","object":"IL-17","context":"in a mouse model of IBD","subject":"Metformin","work_id":268113,"claim_id":211254,"polarity":"positive","predicate":"inhibits","confidence":0.9,"extraction_run_id":31},{"side":"drug_mediator","object":"IL-17","context":"in mouse colitis model","subject":"Metformin","work_id":270824,"claim_id":224127,"polarity":"positive","predicate":"downregulates","confidence":0.85,"extraction_run_id":31},{"side":"mediator_outcome","object":"idiopathic epilepsy","context":"in CSF and serum samples from dogs","subject":"IL-17","work_id":40166,"claim_id":22602,"polarity":"positive","predicate":"associated_with","confidence":0.9,"extraction_run_id":14}],"extracted_claim_count":3,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[14,31]},"bridge":{"a_to_b_predicate":"downregulates","b_to_c_predicate":"associated_with","a_to_b_evidence_count":2,"b_to_c_evidence_count":1,"edge_support_log_ab":1.0986122886681098,"edge_support_log_bc":0.6931471805599453,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.1791759469228055,"score":0.26876392038420827,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:40.945575+00:00"}