{"schema_version":"1.0","hypothesis_id":32331,"triple":{"drug":"LWE","drug_canonical":"lwe","mediator":"SOD1","mediator_canonical":"SOD1","outcome":"familial ALS","outcome_canonical":"familial als"},"domain":{"domain":"cross_domain","source":"inflammatory_bowel_disease","target":"als"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.4103/nrr.nrr-d-24-00701","pmid":"41673790","year":2025,"roles":["mediator_outcome"],"title":"Comprehensive clinical and genetic architecture of familial amyotrophic lateral sclerosis in China: A 15-year cohort study with 302 families","journal":"Neural Regen Res","work_id":143970,"publication_date":"2025-01-13"},{"doi":"10.3390/antiox13070795","pmid":"39061864","year":2024,"roles":["drug_mediator"],"title":"Hydroethanolic Extract of Lepidium apetalum Willdenow Alleviates Dextran Sulfate Sodium-Induced Colitis by Enhancing Intestinal Barrier Integrity and Inhibiting Oxidative Stress and Inflammasome Activation","journal":"Antioxidants (Basel)","work_id":277394,"publication_date":"2024-06-29"},{"doi":"10.1111/ene.14213","pmid":"32166880","year":2020,"roles":["mediator_outcome"],"title":"Clinical and genetic features of patients with amyotrophic lateral sclerosis in southern China","journal":"Eur J Neurol","work_id":133003,"publication_date":"2020-03-13"},{"doi":null,"pmid":"29504729","year":2018,"roles":["mediator_outcome"],"title":"Possible etiology and treatment of amyotrophic lateral sclerosis.","journal":"Neuro Endocrinol Lett","work_id":137251,"publication_date":"2018-02-01"},{"doi":"10.1111/neup.12303","pmid":"27090969","year":2016,"roles":["mediator_outcome"],"title":"A Japanese familial ALS patient with autonomic failure and a p.Cys146Arg mutation in the gene for SOD1 (<i>SOD1</i>)","journal":"Neuropathology","work_id":137118,"publication_date":"2016-04-18"}],"source_paper_count":5,"extracted_claims":[{"side":"drug_mediator","object":"SOD1","context":"DSS-induced colitis mice","subject":"LWE","work_id":277394,"claim_id":250901,"polarity":"positive","predicate":"upregulates","confidence":0.95,"extraction_run_id":31},{"side":"mediator_outcome","object":"familial ALS","context":"patients with ALS in southern China","subject":"SOD1","work_id":133003,"claim_id":98258,"polarity":"positive","predicate":"associated_with","confidence":0.9,"extraction_run_id":21},{"side":"mediator_outcome","object":"familial ALS","context":"Japanese patient with p.Cys146Arg mutation","subject":"SOD1","work_id":137118,"claim_id":99618,"polarity":"positive","predicate":"associated_with","confidence":0.9,"extraction_run_id":21},{"side":"mediator_outcome","object":"familial ALS","context":"mutated SOD1","subject":"SOD1","work_id":137251,"claim_id":99812,"polarity":"positive","predicate":"causes","confidence":0.9,"extraction_run_id":21},{"side":"mediator_outcome","object":"familial ALS","context":"Chinese cohort","subject":"SOD1","work_id":143970,"claim_id":103058,"polarity":"positive","predicate":"associated_with","confidence":0.9,"extraction_run_id":21}],"extracted_claim_count":5,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[21,31]},"bridge":{"a_to_b_predicate":"upregulates","b_to_c_predicate":"associated_with","a_to_b_evidence_count":1,"b_to_c_evidence_count":4,"edge_support_log_ab":0.6931471805599453,"edge_support_log_bc":1.6094379124341003,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.23025850929940456,"score":0.23025850929940456,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:40.945575+00:00"}