{"schema_version":"1.0","hypothesis_id":32135,"triple":{"drug":"TTFields","drug_canonical":"ttfields","mediator":"TXNIP","mediator_canonical":"txnip","outcome":"type 2 diabetes","outcome_canonical":"type 2 diabetes"},"domain":{"domain":"cross_domain","source":"glioblastoma","target":"type_2_diabetes"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1016/j.neurot.2025.e00715","pmid":"40885689","year":2025,"roles":["drug_mediator"],"title":"Tumor treating fields alter local coagulation dynamics in glioblastoma patients","journal":"Neurotherapeutics","work_id":8925,"publication_date":"2025-08-29"},{"doi":"10.1210/clinem/dgab488","pmid":"34214161","year":2021,"roles":["mediator_outcome"],"title":"DNA Methylation Changes Associated With Type 2 Diabetes and Diabetic Kidney Disease in an East Asian Population","journal":"J Clin Endocrinol Metab","work_id":237439,"publication_date":"2021-07-02"},{"doi":"10.1093/ije/dyy171","pmid":"30107520","year":2018,"roles":["mediator_outcome"],"title":"Epigenome-wide association study in whole blood on type 2 diabetes among sub-Saharan African individuals: findings from the RODAM study","journal":"Int J Epidemiol","work_id":233879,"publication_date":"2018-07-25"},{"doi":"10.1186/s13148-016-0177-6","pmid":"26823690","year":2016,"roles":["mediator_outcome"],"title":"Epigenetic associations of type 2 diabetes and BMI in an Arab population","journal":"Clin Epigenetics","work_id":233013,"publication_date":"2016-01-27"}],"source_paper_count":4,"extracted_claims":[{"side":"drug_mediator","object":"TXNIP","context":"in GBM cells","subject":"TTFields","work_id":8925,"claim_id":9389,"polarity":"positive","predicate":"downregulates","confidence":0.9,"extraction_run_id":9},{"side":"mediator_outcome","object":"type 2 diabetes","context":"in whole blood DNA from Qatari and UK cohorts","subject":"TXNIP","work_id":233013,"claim_id":166835,"polarity":"positive","predicate":"associated_with","confidence":0.9,"extraction_run_id":27},{"side":"mediator_outcome","object":"type 2 diabetes","context":"in whole blood of Ghanaian participants from the RODAM study","subject":"TXNIP","work_id":233879,"claim_id":169068,"polarity":"positive","predicate":"associated_with","confidence":0.95,"extraction_run_id":27},{"side":"mediator_outcome","object":"type 2 diabetes","context":"in a Korean population using peripheral blood leukocytes","subject":"TXNIP","work_id":237439,"claim_id":177797,"polarity":"positive","predicate":"associated_with","confidence":0.9,"extraction_run_id":27}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[9,27]},"bridge":{"a_to_b_predicate":"downregulates","b_to_c_predicate":"associated_with","a_to_b_evidence_count":1,"b_to_c_evidence_count":3,"edge_support_log_ab":0.6931471805599453,"edge_support_log_bc":1.3862943611198906,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.20794415416798356,"score":0.20794415416798356,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:40.945575+00:00"}