{"schema_version":"1.0","hypothesis_id":32008,"triple":{"drug":"osimertinib","drug_canonical":"osimertinib","mediator":"EGFR","mediator_canonical":"EGFR","outcome":"rheumatoid arthritis","outcome_canonical":"rheumatoid arthritis"},"domain":{"domain":"cross_domain","source":"glioblastoma","target":"rheumatoid_arthritis"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.14744/anatoljcardiol.2025.5375","pmid":"40964982","year":2025,"roles":["mediator_outcome"],"title":"Selection of Common Genes Associated with Rheumatoid Arthritis and Cardiovascular Disease via a Network- and Pathway-Based Approach","journal":"Anatol J Cardiol","work_id":300105,"publication_date":"2025-01-01"},{"doi":null,"pmid":"36247278","year":2022,"roles":["mediator_outcome"],"title":"Identification and validation of potential hub genes in rheumatoid arthritis by bioinformatics analysis.","journal":"Am J Transl Res","work_id":301576,"publication_date":"2022-01-01"},{"doi":"10.1093/neuonc/noz206","pmid":"31678994","year":2019,"roles":["drug_mediator"],"title":"Betacellulin drives therapy resistance in glioblastoma","journal":"Neuro Oncol","work_id":6904,"publication_date":"2019-10-28"}],"source_paper_count":3,"extracted_claims":[{"side":"drug_mediator","object":"EGFR","context":"in glioblastoma xenografts","subject":"osimertinib","work_id":6904,"claim_id":7943,"polarity":"positive","predicate":"inhibits","confidence":0.9,"extraction_run_id":9},{"side":"mediator_outcome","object":"rheumatoid arthritis","context":"shared gene analysis","subject":"EGFR","work_id":300105,"claim_id":255149,"polarity":"positive","predicate":"associated_with","confidence":0.8,"extraction_run_id":29},{"side":"mediator_outcome","object":"rheumatoid arthritis","context":"in human microarray datasets and rat synovial tissue","subject":"EGFR","work_id":301576,"claim_id":259401,"polarity":"positive","predicate":"associated_with","confidence":0.7,"extraction_run_id":29}],"extracted_claim_count":3,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[9,29]},"bridge":{"a_to_b_predicate":"inhibits","b_to_c_predicate":"associated_with","a_to_b_evidence_count":1,"b_to_c_evidence_count":2,"edge_support_log_ab":0.6931471805599453,"edge_support_log_bc":1.0986122886681098,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.1791759469228055,"score":0.26876392038420827,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:40.211207+00:00"}