{"schema_version":"1.0","hypothesis_id":31942,"triple":{"drug":"Pterostilbene","drug_canonical":"pterostilbene","mediator":"STAT3","mediator_canonical":"STAT3","outcome":"prurigo nodularis","outcome_canonical":"prurigo nodularis"},"domain":{"domain":"cross_domain","source":"glioblastoma","target":"rheumatoid_arthritis"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.4103/ijd.ijd_842_24","pmid":"40162359","year":2025,"roles":["mediator_outcome"],"title":"Successful Use of Tofacitinib in Paediatric Prurigo Nodularis: A Report of Four Cases","journal":"Indian J Dermatol","work_id":293821,"publication_date":"2025-02-27"},{"doi":"10.25259/ijdvl_1017_2024","pmid":"39912139","year":2025,"roles":["mediator_outcome"],"title":"Translating tissue expression of STAT 1, 3 and 6 in prurigo nodularis to clinical efficacy of oral tofacitinib – A prospective single-arm investigational study","journal":"Indian J Dermatol Venereol Leprol","work_id":293624,"publication_date":"2025-01-17"},{"doi":"10.1016/j.intimp.2025.115247","pmid":"40695147","year":2025,"roles":["drug_mediator"],"title":"Pterostilbene as a pyroptosis inducer and tumor microenvironment regulator inhibits glioblastoma and enhances the efficacy of immunotherapy","journal":"Int Immunopharmacol","work_id":5444,"publication_date":"2025-07-21"},{"doi":"10.4103/idoj.idoj_508_22","pmid":"37521237","year":2023,"roles":["mediator_outcome"],"title":"A case of recalcitrant prurigo nodularis with heightened expression of STAT 3 and STAT 6 and its dramatic response to tofacitinib","journal":"Indian Dermatol Online J","work_id":292495,"publication_date":"2023-01-01"}],"source_paper_count":4,"extracted_claims":[{"side":"drug_mediator","object":"STAT3","context":"in glioblastoma cells","subject":"pterostilbene","work_id":5444,"claim_id":6433,"polarity":"positive","predicate":"inhibits","confidence":0.85,"extraction_run_id":8},{"side":"mediator_outcome","object":"prurigo nodularis","context":"in patient lesions","subject":"STAT3","work_id":292495,"claim_id":230479,"polarity":"positive","predicate":"associated_with","confidence":0.8,"extraction_run_id":29},{"side":"mediator_outcome","object":"prurigo nodularis","context":"in lesional skin","subject":"STAT3","work_id":293624,"claim_id":234881,"polarity":"positive","predicate":"associated_with","confidence":0.85,"extraction_run_id":29},{"side":"mediator_outcome","object":"prurigo nodularis","context":"in pathogenesis","subject":"STAT3","work_id":293821,"claim_id":235510,"polarity":"positive","predicate":"associated_with","confidence":0.7,"extraction_run_id":29}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[8,29]},"bridge":{"a_to_b_predicate":"inhibits","b_to_c_predicate":"associated_with","a_to_b_evidence_count":1,"b_to_c_evidence_count":3,"edge_support_log_ab":0.6931471805599453,"edge_support_log_bc":1.3862943611198906,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.20794415416798356,"score":0.20794415416798356,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:40.211207+00:00"}