{"schema_version":"1.0","hypothesis_id":3141,"triple":{"drug":"Isoginkgetin","drug_canonical":"isoginkgetin","mediator":"GSK-3β","mediator_canonical":"GSK3B","outcome":"tau hyperphosphorylation","outcome_canonical":"tau hyperphosphorylation"},"domain":{"domain":"cross_domain","source":"als","target":"alzheimer"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1016/j.phrs.2026.108172","pmid":"41912102","year":2026,"roles":["drug_mediator"],"title":"Isoginkgetin protects against degeneration of ALS motor neurons via regulating the GSK-3β–TFEB signaling axis","journal":"Pharmacol Res","work_id":53628,"publication_date":"2026-03-28"},{"doi":"10.1111/ejn.70364","pmid":"41459736","year":2025,"roles":["mediator_outcome"],"title":"Type 3 Diabetes: A Molecular Link Between Cerebral Insulin Resistance and Neurodegeneration via AGE–RAGE Signaling","journal":"Eur J Neurosci","work_id":149523,"publication_date":"2025-12-29"},{"doi":"10.1016/j.isci.2021.102058","pmid":"33554064","year":2021,"roles":["mediator_outcome"],"title":"Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation","journal":"iScience","work_id":62766,"publication_date":"2021-01-14"}],"source_paper_count":3,"extracted_claims":[{"side":"drug_mediator","object":"GSK-3β","context":"in vitro binding assay","subject":"isoginkgetin","work_id":53628,"claim_id":34700,"polarity":"positive","predicate":"binds_to","confidence":0.9,"extraction_run_id":15},{"side":"drug_mediator","object":"GSK-3β","context":"competitive inhibition at ATP-binding pocket","subject":"isoginkgetin","work_id":53628,"claim_id":34701,"polarity":"positive","predicate":"inhibits","confidence":0.9,"extraction_run_id":15},{"side":"mediator_outcome","object":"tau hyperphosphorylation","context":"in synapses of mouse brain with localized hTau expression","subject":"GSK-3β","work_id":62766,"claim_id":43518,"polarity":"positive","predicate":"increases","confidence":0.9,"extraction_run_id":16},{"side":"mediator_outcome","object":"tau hyperphosphorylation","context":"in Alzheimer's disease","subject":"GSK-3β","work_id":149523,"claim_id":104580,"polarity":"positive","predicate":"increases","confidence":0.8,"extraction_run_id":22}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[15,16,22]},"bridge":{"a_to_b_predicate":"inhibits","b_to_c_predicate":"increases","a_to_b_evidence_count":2,"b_to_c_evidence_count":2,"edge_support_log_ab":1.0986122886681098,"edge_support_log_bc":1.0986122886681098,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.21972245773362195,"score":0.21972245773362195,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:39.496175+00:00"}