{"schema_version":"1.0","hypothesis_id":31397,"triple":{"drug":"acriflavine","drug_canonical":"acriflavine","mediator":"HIF-1α","mediator_canonical":"hif-1α","outcome":"ulcerative colitis","outcome_canonical":"ulcerative colitis"},"domain":{"domain":"cross_domain","source":"glioblastoma","target":"inflammatory_bowel_disease"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1186/s12951-025-03395-x","pmid":"40405165","year":2025,"roles":["drug_mediator"],"title":"Photo-controlled co-delivery of verteporfin and acriflavine via platelets achieves potentiated glioblastoma-targeted photodynamic therapy","journal":"J Nanobiotechnology","work_id":5418,"publication_date":"2025-05-22"},{"doi":"10.3390/biomedicines11123137","pmid":"38137357","year":2023,"roles":["mediator_outcome"],"title":"Interrelation of Hypoxia-Inducible Factor-1 Alpha (HIF-1 α) and the Ratio between the Mean Corpuscular Volume/Lymphocytes (MCVL) and the Cumulative Inflammatory Index (IIC) in Ulcerative Colitis","journal":"Biomedicines","work_id":276815,"publication_date":"2023-11-24"},{"doi":"10.1096/fj.201902103r","pmid":"31944416","year":2020,"roles":["mediator_outcome"],"title":"Mucosal inflammation downregulates PHD1 expression promoting a barrier‐protective HIF‐1α response in ulcerative colitis patients","journal":"FASEB J","work_id":270377,"publication_date":"2020-01-16"}],"source_paper_count":3,"extracted_claims":[{"side":"drug_mediator","object":"HIF-1α","context":"in glioblastoma cells","subject":"acriflavine","work_id":5418,"claim_id":6408,"polarity":"positive","predicate":"inhibits","confidence":0.95,"extraction_run_id":8},{"side":"mediator_outcome","object":"ulcerative colitis","context":"in mucosa","subject":"HIF-1α","work_id":270377,"claim_id":222194,"polarity":"positive","predicate":"prevents","confidence":0.8,"extraction_run_id":31},{"side":"mediator_outcome","object":"ulcerative colitis","context":"in patients with early forms of UC","subject":"HIF-1α","work_id":276815,"claim_id":249005,"polarity":"positive","predicate":"predicts","confidence":0.85,"extraction_run_id":31}],"extracted_claim_count":3,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[8,31]},"bridge":{"a_to_b_predicate":"inhibits","b_to_c_predicate":"prevents","a_to_b_evidence_count":1,"b_to_c_evidence_count":2,"edge_support_log_ab":0.6931471805599453,"edge_support_log_bc":1.0986122886681098,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.1791759469228055,"score":0.26876392038420827,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:40.211207+00:00"}