{"schema_version":"1.0","hypothesis_id":30333,"triple":{"drug":"long-term ketogenic diet","drug_canonical":"long-term ketogenic diet","mediator":"TCF7L2","mediator_canonical":"tcf7l2","outcome":"type 2 diabetes","outcome_canonical":"type 2 diabetes"},"domain":{"domain":"cross_domain","source":"epilepsy","target":"type_2_diabetes"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1016/j.jnha.2024.100427","pmid":"39662156","year":2024,"roles":["drug_mediator"],"title":"Differential effects of short-term and long-term ketogenic diet on gene expression in the aging mouse brain","journal":"J Nutr Health Aging","work_id":45723,"publication_date":"2024-12-10"},{"doi":"10.1038/s41598-019-44076-8","pmid":"31123324","year":2019,"roles":["mediator_outcome"],"title":"ATAC-seq reveals alterations in open chromatin in pancreatic islets from subjects with type 2 diabetes","journal":"Sci Rep","work_id":235958,"publication_date":"2019-05-23"},{"doi":"10.1007/s00125-019-4880-7","pmid":"31049640","year":2019,"roles":["mediator_outcome"],"title":"Genome-wide association study of type 2 diabetes in 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population","subject":"TCF7L2","work_id":248403,"claim_id":202204,"polarity":"positive","predicate":"associated_with","confidence":0.9,"extraction_run_id":27}],"extracted_claim_count":8,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[14,27]},"bridge":{"a_to_b_predicate":"activates","b_to_c_predicate":"associated_with","a_to_b_evidence_count":1,"b_to_c_evidence_count":7,"edge_support_log_ab":0.6931471805599453,"edge_support_log_bc":2.0794415416798357,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.2772588722239781,"score":0.2772588722239781,"quality_tier":"high","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:40.211207+00:00"}