{"schema_version":"1.0","hypothesis_id":2304,"triple":{"drug":"EGCG-SeNPs","drug_canonical":"egcg-senps","mediator":"GFAP","mediator_canonical":"GFAP","outcome":"Alzheimer disease","outcome_canonical":"Alzheimer disease"},"domain":{"domain":"cross_domain","source":"epilepsy","target":"alzheimer"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1093/clinchem/hvaf120","pmid":"41081630","year":2025,"roles":["mediator_outcome"],"title":"Age-Specific Control and Alzheimer Disease Reference Curves and <i>z</i> -Scores for Glial Fibrillary Acidic Protein in Blood","journal":"Clin Chem","work_id":64267,"publication_date":"2025-09-19"},{"doi":"10.3390/biomedicines11071955","pmid":"37509594","year":2023,"roles":["drug_mediator"],"title":"Biosynthesized Selenium Nanoparticles Using Epigallocatechin Gallate Protect against Pentylenetetrazole-Induced Acute Epileptic Seizures in Mice via Antioxidative, Anti-Inflammatory, and Anti-Apoptotic Activities","journal":"Biomedicines","work_id":32463,"publication_date":"2023-07-11"},{"doi":"10.3389/fnagi.2018.00122","pmid":"29755340","year":2018,"roles":["mediator_outcome"],"title":"Glutamate Transporter GLT1 Expression in Alzheimer Disease and Dementia With Lewy Bodies","journal":"Front Aging Neurosci","work_id":64390,"publication_date":"2018-04-26"}],"source_paper_count":3,"extracted_claims":[{"side":"drug_mediator","object":"GFAP","context":"in mice with PTZ-induced seizures","subject":"EGCG-SeNPs","work_id":32463,"claim_id":16350,"polarity":"positive","predicate":"downregulates","confidence":0.85,"extraction_run_id":14},{"side":"mediator_outcome","object":"Alzheimer disease","context":"serum","subject":"GFAP","work_id":64267,"claim_id":46971,"polarity":"positive","predicate":"associated_with","confidence":0.9,"extraction_run_id":16},{"side":"mediator_outcome","object":"Alzheimer disease","context":"early-onset age group","subject":"GFAP","work_id":64267,"claim_id":46973,"polarity":"positive","predicate":"predicts","confidence":0.6,"extraction_run_id":16},{"side":"mediator_outcome","object":"Alzheimer Disease","context":"in AD brain","subject":"GFAP","work_id":64390,"claim_id":47240,"polarity":"positive","predicate":"increases","confidence":0.9,"extraction_run_id":16}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[14,16]},"bridge":{"a_to_b_predicate":"downregulates","b_to_c_predicate":"associated_with","a_to_b_evidence_count":1,"b_to_c_evidence_count":3,"edge_support_log_ab":0.6931471805599453,"edge_support_log_bc":1.3862943611198906,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.20794415416798356,"score":0.20794415416798356,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:39.496175+00:00"}