{"schema_version":"1.0","hypothesis_id":2095,"triple":{"drug":"Ketogenic diet","drug_canonical":"ketogenic diet","mediator":"Kynurenine","mediator_canonical":"kynurenine","outcome":"ALS","outcome_canonical":"amyotrophic lateral sclerosis"},"domain":{"domain":"cross_domain","source":"epilepsy","target":"als"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.3233/jad-215411","pmid":"35275534","year":2022,"roles":["mediator_outcome"],"title":"Investigating Casual Associations Among Gut Microbiota, Metabolites, and Neurodegenerative Diseases: A Mendelian Randomization Study","journal":"J Alzheimers Dis","work_id":50358,"publication_date":"2022-03-08"},{"doi":"10.3390/biom11050691","pmid":"34063031","year":2021,"roles":["mediator_outcome"],"title":"Some CSF Kynurenine Pathway Intermediates Associated with Disease Evolution in Amyotrophic Lateral Sclerosis","journal":"Biomolecules","work_id":52582,"publication_date":"2021-05-05"},{"doi":"10.1194/jlr.m079251","pmid":"29605816","year":2018,"roles":["drug_mediator"],"title":"Regulation of kynurenine metabolism by a ketogenic diet","journal":"J Lipid Res","work_id":33435,"publication_date":"2018-01-01"}],"source_paper_count":3,"extracted_claims":[{"side":"drug_mediator","object":"kynurenine","context":"in rat plasma, compared to control diet ad libitum","subject":"ketogenic diet","work_id":33435,"claim_id":17475,"polarity":"positive","predicate":"downregulates","confidence":0.9,"extraction_run_id":14},{"side":"drug_mediator","object":"kynurenine","context":"in rat hippocampus, compared to control diet ad libitum","subject":"ketogenic diet","work_id":33435,"claim_id":17474,"polarity":"positive","predicate":"downregulates","confidence":0.9,"extraction_run_id":14},{"side":"mediator_outcome","object":"ALS","context":"serotonin pathway","subject":"Kynurenine","work_id":50358,"claim_id":28226,"polarity":"positive","predicate":"increases","confidence":0.8,"extraction_run_id":15},{"side":"mediator_outcome","object":"ALS","context":"CSF at diagnosis","subject":"kynurenine","work_id":52582,"claim_id":32911,"polarity":"positive","predicate":"associated_with","confidence":0.6,"extraction_run_id":15}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[14,15]},"bridge":{"a_to_b_predicate":"downregulates","b_to_c_predicate":"increases","a_to_b_evidence_count":2,"b_to_c_evidence_count":2,"edge_support_log_ab":1.0986122886681098,"edge_support_log_bc":1.0986122886681098,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.21972245773362195,"score":0.21972245773362195,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:39.496175+00:00"}