{"schema_version":"1.0","hypothesis_id":19718,"triple":{"drug":"glycyrrhizin","drug_canonical":"glycyrrhizin","mediator":"HMGB1","mediator_canonical":"HMGB1","outcome":"Multiple Sclerosis","outcome_canonical":"multiple sclerosis"},"domain":{"domain":"cross_domain","source":"als","target":"multiple_sclerosis"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1097/cm9.0000000000003806","pmid":"41139682","year":2025,"roles":["drug_mediator"],"title":"Therapeutic potential of glycyrrhizin in nervous system diseases","journal":"Chin Med J (Engl)","work_id":142979,"publication_date":"2025-10-27"},{"doi":"10.4103/0028-3886.338707","pmid":"35263889","year":2022,"roles":["mediator_outcome"],"title":"Does the Serum Expression Level of High-Mobility Group Box 1 (HMGB1) in Multiple Sclerosis Patients have a Relationship with Physical and Psychological Status? A 12-Month Follow-Up Study on Newly Diagnosed MS Patients","journal":"Neurol India","work_id":205939,"publication_date":"2022-01-01"},{"doi":"10.4149/bll_2019_120","pmid":"31663345","year":2019,"roles":["mediator_outcome"],"title":"Decreased plasma levels of 25(OH)D in multiple sclerosis patients. Correlation with disease severity expressed by EDSS, MSSS, progression index and Herbert´s scale severity grade","journal":"Bratisl Lek Listy","work_id":207020,"publication_date":"2019-01-01"}],"source_paper_count":3,"extracted_claims":[{"side":"drug_mediator","object":"HMGB1","context":"in nervous system diseases","subject":"Glycyrrhizin","work_id":142979,"claim_id":102414,"polarity":"positive","predicate":"inhibits","confidence":0.95,"extraction_run_id":21},{"side":"drug_mediator","object":"HMGB1","context":"general","subject":"Glycyrrhizin","work_id":142979,"claim_id":102415,"polarity":"positive","predicate":"binds_to","confidence":0.95,"extraction_run_id":21},{"side":"mediator_outcome","object":"multiple sclerosis","context":"newly diagnosed MS patients vs healthy controls","subject":"HMGB1","work_id":205939,"claim_id":155899,"polarity":"positive","predicate":"associated_with","confidence":0.9,"extraction_run_id":25},{"side":"mediator_outcome","object":"multiple sclerosis","context":"higher levels in plasma of MS patients","subject":"HMGB1","work_id":207020,"claim_id":157211,"polarity":"positive","predicate":"associated_with","confidence":0.9,"extraction_run_id":25}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[21,25]},"bridge":{"a_to_b_predicate":"binds_to","b_to_c_predicate":"associated_with","a_to_b_evidence_count":2,"b_to_c_evidence_count":2,"edge_support_log_ab":1.0986122886681098,"edge_support_log_bc":1.0986122886681098,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.21972245773362195,"score":0.21972245773362195,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:40.211207+00:00"}